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Synthesis, Characterization and Mri Application of Cobalt-Zinc Ferrite Nanoparticles Coated With Dmsa: An In-Vivo Study Publisher



Ansari L1 ; Sharifi I2 ; Ghadrijan H3 ; Azarpira N4, 5 ; Momeni F1 ; Zamani H6 ; Rasouli N3 ; Mohammadi M7 ; Mehdizadeh A1, 8 ; Abedifirouzjah R9
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Material Engineering, Faculty of Engineering, Shahrekord University, Shahrekord, Iran
  3. 3. Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

Source: Applied Magnetic Resonance Published:2021


Abstract

The aim of this study was to synthesize and characterize the dimercaptosuccinic acid (DMSA) cobalt–zinc (Co–Zn) ferrite magnetic nanoparticles (NPs) and their efficiency as a contrast agent in in vivo MR imaging of rat liver. Co–Zn ferrite NPs were synthesized by the thermal decomposition method and stabilized by DMSA. The NPs were characterized by different analyses to study their physical and magnetic properties and were injected into 6 adult male rats. Liver MRI was performed to measure the signal intensity at different times. The average nanoparticle size was estimated at about 8 ± 1 nm using transmission electron microscopy (TEM). The r2 and r2* relaxivity of these particles were obtained at 32.85 and 168.96 mmol L−1 s−1, respectively, using an agarose phantom imaged by MRI. In the in vivo condition, injection of SNPs (2.5 mg Fe/kg) showed negative contrast in a way that for T2 and T2* weighted the maximum contrast enhancement was 58.46 and 77.13%, respectively. Regarding our results, the synthesized Co–Zn ferrite NPs stabilized by DMSA are appropriate agents for increasing the contrast in both T2 and T2* weighted based on MR imaging in rat liver. © 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
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