Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Associations of Unprocessed and Processed Meat Intake With Mortality and Cardiovascular Disease in 21 Countries [Prospective Urban Rural Epidemiology (Pure) Study]: A Prospective Cohort Study Publisher Pubmed



Iqbal R1 ; Dehghan M2 ; Mente A2 ; Rangarajan S2 ; Wielgosz A3 ; Avezum A4 ; Seron P5 ; Alhabib KF6 ; Lopezjaramillo P7 ; Swaminathan S8 ; Mohammadifard N9 ; Zatonska K10 ; Bo H11 ; Varma RP12 Show All Authors
Authors
  1. Iqbal R1
  2. Dehghan M2
  3. Mente A2
  4. Rangarajan S2
  5. Wielgosz A3
  6. Avezum A4
  7. Seron P5
  8. Alhabib KF6
  9. Lopezjaramillo P7
  10. Swaminathan S8
  11. Mohammadifard N9
  12. Zatonska K10
  13. Bo H11
  14. Varma RP12
  15. Rahman O13
  16. Yusufali A14
  17. Lu Y11
  18. Ismail N15
  19. Rosengren A16
  20. Imeryuz N17
  21. Yeates K18
  22. Chifamba J19
  23. Dans A20
  24. Kumar R21
  25. Xiaoyun L11
  26. Tsolekile L22
  27. Khatib R23, 24
  28. Diaz R25
  29. Teo K2
  30. Yusuf S2

Source: American Journal of Clinical Nutrition Published:2021


Abstract

Background: Dietary guidelines recommend limiting red meat intake because it is a major source of medium- and long-chain SFAs and is presumed to increase the risk of cardiovascular disease (CVD). Evidence of an association between unprocessed red meat intake and CVD is inconsistent. Objective: The study aimed to assess the association of unprocessed red meat, poultry, and processed meat intake with mortality and major CVD. Methods: The Prospective Urban Rural Epidemiology (PURE) Study is a cohort of 134,297 individuals enrolled from 21 low-, middle-, and high-income countries. Food intake was recorded using country-specific validated FFQs. The primary outcomes were total mortality and major CVD. HRs were estimated using multivariable Cox frailty models with random intercepts. Results: In the PURE study, during 9.5 y of follow-up, we recorded 7789 deaths and 6976 CVD events. Higher unprocessed red meat intake (≥250 g/wk vs. <50 g/wk) was not significantly associated with total mortality (HR: 0.93; 95% CI: 0.85, 1.02; P-trend = 0.14) or major CVD (HR: 1.01; 95% CI: 0.92, 1.11; P-trend = 0.72). Similarly, no association was observed between poultry intake and health outcomes. Higher intake of processed meat (≥150 g/wk vs. 0 g/wk) was associated with higher risk of total mortality (HR: 1.51; 95% CI: 1.08, 2.10; P-trend = 0.009) and major CVD (HR: 1.46; 95% CI: 1.08, 1.98; P-trend = 0.004). Conclusions: In a large multinational prospective study, we did not find significant associations between unprocessed red meat and poultry intake and mortality or major CVD. Conversely, a higher intake of processed meat was associated with a higher risk of mortality and major CVD. © 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Other Related Docs