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Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application Publisher Pubmed



Jiao X1 ; Ashtari N1 ; Balaei MR1 ; Chen QM1 ; Badbezanchi I1 ; Shojaei S2 ; Marzban A3 ; Mirzaei N1 ; Chung S4 ; Guan T1 ; Li J1 ; Vriend J1 ; Mehr SE5 ; Kong J1 Show All Authors
Authors
  1. Jiao X1
  2. Ashtari N1
  3. Balaei MR1
  4. Chen QM1
  5. Badbezanchi I1
  6. Shojaei S2
  7. Marzban A3
  8. Mirzaei N1
  9. Chung S4
  10. Guan T1
  11. Li J1
  12. Vriend J1
  13. Mehr SE5
  14. Kong J1
  15. Marzban H1
Show Affiliations
Authors Affiliations
  1. 1. Department of Human Anatomy and Cell Science, Manitoba Institute of Child Health (MICH), Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
  2. 2. Department of Clinical Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, 60612, IL, United States
  5. 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Molecular Pharmacology Published:2016


Abstract

The mevalonate cascade is a key metabolic pathway that regulates a variety of cellular functions and is thereby implicated in the pathophysiology of most brain diseases, including neurodevelopmental and neurodegenerative disorders. Emerging lines of evidence suggest that statins and Rho GTPase inhibitors are efficacious and have advantageous properties in treatment of different pathologic conditions that are relevant to the central nervous system. Beyond the original role of statins in lowering cholesterol synthesis, they have anti-inflammatory, antioxidant and modulatory effects on signaling pathways. Additionally, Rho GTPase inhibitors and statins share the mevalonate pathway as a common target of their therapeutic actions. In this review, we discuss potential mechanisms through which these drugs, via their role in the mevalonate pathway, exert their neuroprotective effects in neurodegenerative and neurodevelopmental disorders. © 2016 Bentham Science Publishers.
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