Treatment of Hormone Resistance With Docetaxel in Metastatic Prostate Cancer Patients: Results of a Clinical Experience at Omid Hospital, Isfahan, Iran



Tajvidi M¹ ; Roayaei M¹ ; Hematti S¹ ; Faezi H¹ Show Affiliations
Source: Middle East Journal of Cancer Published:2017

Abstract

Background: Metastatic prostate cancer is one of the most important cancers among men worldwide. Androgen ablation therapy can be used in treatment of these patients; however, most will progress to metastatic hormone-refractory prostate cancer. In this regard, docetaxel has been approved to treat metastatic hormone-refractory prostate cancer in the United States. In this study, we aimed to investigate the results of this treatment modality in metastatic prostate cancer patients from Iran. Methods: We evaluated PSA response and bone pain relief in 18 metastatic prostate cancer patients who underwent treatment with docetaxel at a dose of 75 mg/m2intravenously on the first day of treatment. The treatment was repeated every three weeks (6 cycles) along with 10 mg of prednisolone. Results: Of 18 patients, 39% had >50% decline in PSA levels. There were 16% of the patients with a PSA decline of approximately 30% to 50% of the pre-treatment levels. In addition, 29% of the patients had progressive PSA levels during chemotherapy. Among them, 55% had significant pain relief. Conclusion: This research showed the effectiveness of docetaxel to decrease PSA levels in metastatic hormone-refractory prostate cancer patients from Iran. Docetaxel was also valuable in alleviation of pain in these patients. However, prospective studies should validate this approach. © 2016, Shiraz University of Medical Sciences. All rights reserved.