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Isolation and Identification of Ferulic Acid From Aerial Parts of Kelussia Odoratissima Mozaff Publisher



Sajjadi SE1 ; Shokoohinia Y2 ; Moayedi NS3
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, IR, Iran
  2. 2. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, IR, Iran
  3. 3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IR, Iran

Source: Jundishapur Journal of Natural Pharmaceutical Products Published:2012


Abstract

Background: Kelussia odoratissima mozaff.is one of the newest genera of umbelliferae which is represented by only one species. This sweet-smelling, self-growing monotypic medicinal plant is endemic to a restricted area in west of Iran and is locally called Karafse-koohi. The aerial parts of the plant are commonly used as a popular garnish and a sedative medicinal plant. There are several reports concerning antioxidant, antiinflammatory, anxiolytic and hypolipidemic activities of aerial parts of K. odoratissima. Objectives: The current research aimed to evaluate some phenolic contents of the plant for the first time .It is confirmed that secondary metabolites and especially phenolic compounds have important role in the biological activities of the plant. Available information indicates that phenolic contents of K. odoratissima have not been the subject of any investigation Material and Methods: Aerial parts of K. odoratissima were extracted with acetone by maceration method. Normal and reversed phase vacuum liquid chromatography used to fractionate the extract. 1H-NMR, 13CNMR, EI-Mass and IR spectra were used to elucidate isolated compound. Results: The phenolic acid isolated compound was identified as 4-hydroxy-3-methoxycinnamic acid (ferulic acid). Conclusions: Compared with previous reported antioxidant and anti-inflammatory properties of ferulic acid, a chemical-biological relation can be postulated.© 2012 School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp.
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