Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Biological and Pharmacological Effects and Nutritional Impact of Phytosterols: A Comprehensive Review Publisher Pubmed

Summary: A review suggests plant compounds may cut cholesterol and cancer risk by 20%, promoting heart health. #HeartHealth #Nutrition

Nattagheshtivani E1, 2 ; Barghchi H2 ; Pahlavani N3, 4 ; Barati M5 ; Amiri Y6 ; Fadel A7 ; Khosravi M2 ; Talebi S2 ; Arzhang P8 ; Ziaei R9 ; Ghavami A9
Authors

Source: Phytotherapy Research Published:2022


Abstract

Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health-promoting effects of PSs include anti-obesity, anti-diabetic, anti-microbial, anti-inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol-rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs. © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Effects of Phytosterols Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis, Clinical Nutrition (2020)
2. Possible Anti-Obesity Effects of Phytosterols and Phytostanols Supplementation in Humans: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2019)
3. Phytosterol Supplementation Could Improve Atherogenic and Anti-Atherogenic Apolipoproteins: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Journal of the American College of Nutrition (2020)
Experts (# of related papers)
View all Related Experts
Abed Ghavami (4)
Rahele Ziaei (3)
Biological and Pharmacological Effects and Nutritional Impact of Phytosterols: A Comprehensive Review
Other Related Docs
4. Effects of Phytosterols Supplementation on Blood Glucose, Glycosylated Hemoglobin (Hba1c) and Insulin Levels in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Diabetes and Metabolic Disorders (2020)
5. Effects of Momordica Charantia L on Blood Pressure: A Systematic Review and Meta- Analysis of Randomized Clinical Trials, International Journal of Food Properties (2020)
6. Effects of Artichoke on Blood Pressure: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2021)
7. The Beneficial Effects of Nutraceuticals and Natural Products on Small Dense Ldl Levels, Ldl Particle Number and Ldl Particle Size: A Clinical Review, Lipids in Health and Disease (2020)
8. Potential of Favorable Effects of Probiotics Fermented Milk Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis, International Journal of Food Properties (2020)
9. Medicinal Plants and Bioactive Natural Compounds As Inhibitors of Hmg-Coa Reductase: A Literature Review, BioFactors (2020)
10. Impact of Cacao Consumption on Cardiovascular Risk Factors: Review of Current Evidence, Journal of Isfahan Medical School (2010)
11. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
12. In Reply to Letter to Editor (Meta-Analysis of Phytosterols Supplementation and Blood Pressure: A Concern Regarding Misleading Data), Clinical Nutrition (2020)
13. A Review of Plant‑Based Compounds and Medicinal Plants Effective on Atherosclerosis, Journal of Research in Medical Sciences (2017)
14. Cardiovascular Protective Effects of Cinnamic Acid As a Natural Phenolic Acid: A Review, Archives of Physiology and Biochemistry (2025)
15. Consumption of Pistachio Nuts Positively Affects Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2023)
16. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats, Pakistan Journal of Biological Sciences (2014)
17. Association of Omega-6 Polyunsaturated Fatty Acids With Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies, Critical Reviews in Food Science and Nutrition (2023)
18. Effects of Strawberry Supplementation on Cardiovascular Risk Factors: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials, Food and Function (2019)
19. Effects of Olive Leaves Extract on Ldl Oxidation Induced-Cuso 4In Vitro, Pakistan Journal of Pharmaceutical Sciences (2012)
20. The Effects of Phytochemicals on Serum Triglycerides in Subjects With Hypertriglyceridemia: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)