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Topical Sucralfate for Treatment of Mucocutaneous Conditions: A Systematic Review on Clinical Evidences Publisher Pubmed



Abtahinaeini B1, 2 ; Saffaei A3, 4 ; Sabzghabaee AM5 ; Amiri R6 ; Hosseini NS7 ; Niknami E8 ; Dehghani S7
Authors
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Authors Affiliations
  1. 1. Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Dermatologic Therapy Published:2022


Abstract

Sucralfate is an aluminum salt of sucrose octasulfate, generally considered safe in terms of adverse effects. Systemic sucralfate is FDA-approved for the treatment of duodenal ulcers. Since 1991, topical sucralfate has been used in various mucocutaneous conditions, but it is not approved by the FDA yet. In this systematic review, the online databases were searched with appropriate keywords, and the papers were screened by the authors. After screening steps, the relevant articles were selected according to the inclusions and exclusions criteria. Finally, the full texts of 18 articles were included for final evaluations. In conclusion, topical sucralfate has some clinical benefit in several mucocutaneous conditions, including mucocutaneous inflammatory conditions (e.g., post-radiotherapy reaction, diaper dermatitis, keratoconjunctivitis sicca, etc.), mucocutaneous infectious disorders (e.g., peristomal wound reaction/infection); ulcers; burns, and also pain relief. © 2022 Wiley Periodicals LLC.
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