Overexpression of Long Non‑Coding Rnas Mcm3ap‑As1 and Linc00092 Predict Poor Prognosis in Patients With Gastric Adenocarcinoma Publisher

Summary: LINC00092 & MCM3AP‑AS1 overexpression linked to gastric cancer severity. They may serve as prognostic markers. What does this mean for treatment strategies? #GastricCancer #LncRNA

Bagheri M ; Aghaabdollahian S ; Asghardoust Rezaei M ; Gholian Kholerdi AM ; Mehdi M ; Keyvanloo Shahrestanaki M
Source: Advanced Biomedical Research Published:2024

Abstract

Background: LINC00092 and MCM3AP‑AS1 long non‑coding RNAs (LncRNAs) play significant roles in the development and pathogenesis of many cancers. However, their expression levels and prognostic values were not evaluated in human gastric adenocarcinoma (GAC). Therefore, the present study aimed to investigate the clinico‑pathological correlations of LINC00092 and MCM3AP‑AS1, LncRNAs expression in GAC, and evaluate their prognostic values. Materials and Methods: The expression of LINC00092 and MCM3AP‑AS1 was detected in 89 GAC tissues by quantitative real‑time reverse‑transcription PCR (qRT‑PCR). Results: Our results showed that LINC00092 and MCM3AP‑AS1 are overexpressed in GAC patients and positively correlated with GAC invasion and vascular, peritoneal, and lymph node metastasis (P < 0.05). Furthermore, the results indicated that MCM3AP‑AS1 (P = 0.0225) and LINC00092 (P < 0.001) have positive correlations with GAC patients’ overall survival. Conclusion: Altogether, the present results indicated that LINC00092 and MCM3AP‑AS1 overexpression is associated with clinico‑pathological characteristic of GAC patients. In addition, both of these LncRNAs may have prognostic value for estimation of patients’ overall survival. © 2025 Elsevier B.V., All rights reserved.