The Antioxidant and Anti-Inflammatory Effects of Astaxanthin Supplementation on the Expression Of Mir-146A and Mir-126 in Patients With Type 2 Diabetes Mellitus: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Shokrimashhadi N^{1, 2} ; Tahmasebi M^{3, 4} ; Mohammadiasl J⁵ ; Zakerkish M⁶ ; Mohammadshahi M²
Source: International Journal of Clinical Practice Published:2021

Abstract

Background: The pathogenesis of type 2 diabetes mellitus (T2DM) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA-146a is upregulated in diabetic and hyperglycaemic patients, whereas circulating miRNA-126 is reduced. Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM. Methods: This randomised, double-blind, placebo-controlled clinical trial was conducted in 44 patients with T2DM randomly receiving 8 mg/d of oral AST (n = 22) or placebo (n = 22) for 8 weeks. Results: We observed that AST supplementation could decrease plasma levels of MDA and IL-6 (P <.05) and decrease the expression level of miR-146a over time (fold change: −1/388) (P <.05). Conclusion: AST supplementation might be beneficial for improving circulating MDA and IL-6 and the down-regulation of miR-146a. However, future investigations are suggested to confirm these results. © 2021 John Wiley & Sons Ltd