Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Viral Infection in Implantation Failure: Direct and Indirect Effects Publisher Pubmed



Rezaei M1 ; Moghoofei M2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Infectious Diseases Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Reproductive Biology and Endocrinology Published:2024


Abstract

Implantation is the key initial complex stage of pregnancy. Several factors are involved in implantation, but acute and controlled inflammation has been shown to play as a key role. On the other hand, the role of viral infections in directly infecting blastocyst and trophoblast and inducing chronic and uncontrolled inflammation and disrupting microRNAs expression can make this review strongly attractive and practical. We aim to provide an overview of viral infections as the potential etiology of unsuccessful implantation pathophysiology through alteration of the cellular and molecular endometrial microenvironment. Based on our search, this is the first review to discuss the role of inflammation associated with viral infection in implantation failure. © The Author(s) 2024.
Related Docs
View other Related Docs
1. Viral Infection in Endometritis: Is There an Important Role or Not?, American Journal of Reproductive Immunology (2024)
2. Ovarian Stimulation and Exogenous Progesterone Affect the Endometrial Mir-16-5P, Vegf Protein Expression, and Angiogenesis, Microvascular Research (2021)
3. Anti-Thyroid Antibodies and Underlying Generalized Immunologic Aberrations in Patients With Reproductive Failures, Journal of Reproductive Immunology (2022)
4. Intrauterine Infusion of Autologous Platelet-Rich Plasma in Women Undergoing Assisted Reproduction: A Systematic Review and Meta-Analysis, Journal of Reproductive Immunology (2020)
5. Identifying Shared Molecular Landscape Between Uterine Fibroids and Recurrent Implantation Failure: An Integrated Bioinformatics Study, Heliyon (2025)
6. Study on Gene Expression of Il-17A in Eutopic and Ectopic Tissue Sample of Endometriosis Patients and Comparison With Control Group, Biomedical Research and Therapy (2024)
7. Evaluating the Effect of Ovarian Stimulation and Exogenous Progesterone on Cd31-Positive Cell Density, Vegf Protein, and Mir-17-5P Expression of Endometrium Immediately Before Implantation, Biomedicine and Pharmacotherapy (2021)
8. The Study of Association Between Polymorphism of Tnf-Α Gene's Promoter Region and Recurrent Pregnancy Loss, Journal of Reproduction and Infertility (2018)
Experts (# of related papers)
View all Related Experts
Bahman Rashidi (3)
Mohammad Kazemi (2)
Other Related Docs
9. Implantation Window and Angiogenesis, Journal of Cellular Biochemistry (2017)
10. Review of the Evidence of the Effects of Human Papillomavirus Infection and Gardnerella Vaginalis, and Their Co-Infection on Infertility, Microbial Pathogenesis (2023)
11. Micrornas in Female Infertility: An Overview, Cell Biochemistry and Function (2021)
12. Mirna, Biogenesis and Mechanisms of Regulations, Journal of Isfahan Medical School (2014)
13. Intrauterine Administration of Autologous Peripheral Blood Mononuclear Cells in Patients With Recurrent Implantation Failure: A Systematic Review and Meta-Analysis, Journal of Reproductive Immunology (2019)
14. Apolipoprotein A1 As a Novel Anti-Implantation Biomarker in Polycystic Ovary Syndrome: A Case-Control Study, Journal of Research in Medical Sciences (2015)