Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Combined Conventional and Modified Ultrafiltration on Mechanical Ventilation and Hemodynamic Changes in Congenital Heart Surgery Publisher



Ziyaeifard M1 ; Alizadehasl A2 ; Aghdaii N1 ; Rahimzadeh P3 ; Masoumi G4 ; Golzari SEJ5 ; Fatahi M6 ; Gorjipur F6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Departments of Cardiac Anesthesiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Departments of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Departments of Anesthesiology and Pain Medicine, Hazrat Rasul Medical Complex, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Departments of Perfusion, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Research in Medical Sciences Published:2016


Abstract

Background: Cardiopulmonary bypass is associated with increased fluid accumulation around the heart which influences pulmonary and cardiac diastolic function. The aim of this study was to compare the effects of modified ultrafiltration (MUF) versus conventional ultrafiltration (CUF) on duration of mechanical ventilation and hemodynamic status in children undergoing congenital heart surgery. Materials and Methods: A randomized clinical trial was conducted on 46 pediatric patients undergoing cardiopulmonary bypass throughout their congenital heart surgery. Arteriovenous MUF plus CUF was performed in 23 patients (intervention group) and sole CUF was performed for other 23 patients (control group). In MUF group, arterial cannula was linked to the filter inlet through the arterial line, and for 10 min, 10 ml/kg/min of blood was filtered and returned via cardioplegia line to the right atrium. Different parameters including hemodynamic variables, length of mechanical ventilation, Intensive Care Unit (ICU) stay, and inotrope requirement were compared between the two groups. Results: At immediate post‑MUF phase, there was a statistically significant increase in the mean arterial pressure, systolic blood pressure, and diastolic blood pressure (P < 0.05) only in the study group. Furthermore, there was a significant difference in time of mechanical ventilation (P = 0.004) and ICU stay (P = 0.007) between the two groups. Inotropes including milrinone (P = 0.04), epinephrine (P = 0.001), and dobutamine (P = 0.002) were used significantly less frequently for patients in the intervention than the control group. Conclusion: Administration of MUF following surgery improves hemodynamic status of patients and also significantly decreases the duration of mechanical ventilation and inotrope requirement within 48 h after surgery. © 2016 Journal of Research in Medical Sciences.
Related Docs
View other Related Docs
1. Effect of Combined Conventional Ultrafiltration and Modified Ultrafiltration on Serum Interleukin-6 and Tnf-Α Levels in Pediatric Cardiac Surgery Patients, Journal of Cellular and Molecular Anesthesia (2019)
2. Comparing the Hemodynamic Effects of Nitroglycerin and Labetalol Infusion for Hypertension and Heart Rate Control Before and During Induction to Cardiopulmonary Arrest in Patients Under Coronary Artery Bypass Graft, Journal of Isfahan Medical School (2016)
3. Effect of Different Dosages of Nitroglycerin Infusion on Arterial Blood Gas Tensions in Patients Undergoing On- Pump Coronary Artery Bypass Graft Surgery, Journal of Research in Medical Sciences (2012)
4. The Efficacy and Safety of Using Amplatzer for Transcatheter Closure of Atrial Septal Defect in Small Children With Less Than 10 Kg, ARYA Atherosclerosis (2019)
5. The Effects of Mean Arterial Pressure During Cardiopulmonary Bypass on Clinical and Paraclinical Parameters During and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2012)
6. Coagulation and Fibrinolytic Protein Kinetics in Cardiopulmonary Bypass, Journal of Thrombosis and Thrombolysis (2009)
7. Postoperative Cardiac Arrest in Children With Congenital Heart Abnormalities, ARYA Atherosclerosis (2013)
8. A Case Series of Pulmonary Hypertension in Small Infants With Atrial Septal Defect, ARYA Atherosclerosis (2020)
Experts (# of related papers)
View all Related Experts
Alireza Ahmadi (4)
Mehran Shahzamani (4)
Other Related Docs
9. Comparison of Two Modes of Ventilation After Fast-Track Cardiac Surgery: Adaptive Support Ventilation Versus Synchronized Intermittent Mandatory Ventilation, Pakistan Journal of Medical Sciences (2012)
10. The Effect of N-Acetylcysteine in Prime Solution on Preventing Renal Failure During Cardiopulmonary Bypass Surgery, Journal of Isfahan Medical School (2021)
11. The Comparison of the Effect of Handmade Del Nido and St. Thomas Cardioplegia Solutions on Quantitative Levels of Troponin I and Creatine Kinase-Myocardial Band (Cpk-Mb) in Repair of Pediatric Ventricular Septal Defect, Journal of Isfahan Medical School (2020)
12. Comparing the Hemodynamic Changes During and After Coronary Artery Bypass Graft Surgery Under General Anesthesia With Propofol and Isoflurane, Journal of Isfahan Medical School (2015)
13. The Relation Between the Mean Time Interval of Opening of Aortic Cross Clamp to the End of Cardiopulmonary Bypass With Surgical Results of Patient After Coronary Artery Bypass Grafting Surgery, Journal of Isfahan Medical School (2017)
14. Comparative Study of Clinical Outcomes of Methylprednisolone and Dexamethasone in Prime Solution During Cardiopulmonary Pump After Coronary Artery Bypass Grafting, Journal of Cellular and Molecular Anesthesia (2021)
15. The Effect of Intravenous Injection of Amiodarone on Central Venous Pressure in Patients Undergoing Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2018)
16. Repair of Atrial Septal Defect Via Right Submammary Minithoracotomy in Children, International Cardiovascular Research Journal (2015)
17. Comparison of the Therapeutic Effects and Side Effects of Tadalafil and Sildenafil After Surgery in Young Infants With Pulmonary Arterial Hypertension Due to Systemic-To-Pulmonary Shunts, Cardiology in the Young (2017)
18. Comparative Effects of Pulmonary Valve Replacement (Pvr) Surgery With Bioprosthetic and Mechanical Valves on Early and Late Outcome of Patients After Congenital Heart Surgeries: 10 Years of Experience, Indian Journal of Thoracic and Cardiovascular Surgery (2014)