Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Inhibitory Potential of Natural Compounds on Α-Amylase and Α-Glucosidase in the Management of Type 2 Diabetes Publisher



Sadeghi M1 ; Miroliaei M1 ; Ghanadian M2 ; Taslimi P3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Biological Science and Technology, Department of Cell and Molecular Biology & Microbiology, University of Isfahan, Isfahan, Iran
  2. 2. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkiye

Source: Iranian Journal of Chemistry and Chemical Engineering Published:2024


Abstract

In an effort to find effective medicines for the treatment of diabetes, the efficient mechanisms and lack of side effects of herbal medicines have made them the main candidates for regulating blood sugar levels and reducing the side effects of the disease. This search will be based on the discovery of digestive enzymes (α-amylase and α-glucosidase) inhibitors from natural sources and the ways to reduce high blood sugar levels. These enzymes are at the forefront of increasing blood glucose levels because they facilitate the digestion of food polysaccharides into smaller monosaccharide in small intestinal wall. Currently, the arsenal of inhibitors approved for this purpose is limited to veglibose, miglitol and acarbose. Despite the ability to reduce glucose absorption their widespread clinical use is limited due to the occurrence of gastrointestinal ailments. Given the efficacy of various natural compounds in alleviating diabetes symptoms, this review aims to assess the inhibitory potential and mode of action of some phytochemicals on intestinal digestive enzymes. Such an exploration seeks to unveil novel and healthful anti-diabetic agents based on the inhibition of digestive enzymes. © 2024, Iranian Institute of Research and Development in Chemical Industries. All rights reserved.
Related Docs
View other Related Docs
1. Exploring the Inhibitory Properties of Biflavonoids on Α-Glucosidase; Computational and Experimental Approaches, International Journal of Biological Macromolecules (2023)
2. Inhibitory Effect of Flavonoid Glycosides on Digestive Enzymes: In Silico, in Vitro, and in Vivo Studies, International Journal of Biological Macromolecules (2022)
3. The Impact of Ages on Human Health and the Development of Their Inhibitors Based on Natural Compounds, Arabian Journal of Chemistry (2023)
4. Drug Repurposing for Diabetes Mellitus: In Silico and in Vitro Investigation of Drugbank Database for Α-Glucosidase Inhibitors, International Journal of Biological Macromolecules (2024)
5. Identification of Cholinesterases Inhibitors From Flavonoids Derivatives for Possible Treatment of Alzheimer's Disease: In Silico and in Vitro Approaches, Current Research in Structural Biology (2024)
6. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)
7. Design and Synthesis of Novel Pyrazole-Phenyl Semicarbazone Derivatives As Potential Α-Glucosidase Inhibitor: Kinetics and Molecular Dynamics Simulation Study, International Journal of Biological Macromolecules (2021)
8. Inhibitory Effect of Hydroalcoholic and Flavonoids Extracts of Dracocephalum Kotschyi, and Its Components Luteolin, Apigenin and Apigenin-4'-Galactoside on Intestinal Transit in Mice, Journal of HerbMed Pharmacology (2019)
Experts (# of related papers)
View all Related Experts
Mustafa Ghanadian (6)
Sedigheh Asgary (5)
Other Related Docs
9. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Pyrazole-Benzofuran Hybrids As New Α-Glucosidase Inhibitor, Scientific Reports (2021)
10. New Concepts in Nutraceuticals As Alternative for Pharmaceuticals, International Journal of Preventive Medicine (2014)
11. Inhibitory Effects of Curcumin on Aldose Reductase and Cyclooxygenase-2 Enzymes, Journal of Biomolecular Structure and Dynamics (2021)
12. The Inhibitory Effects of Pure Flavonoids on in Vitro Protein Glycosylation, Journal of Herbal Pharmacotherapy (2002)
13. Salsalate Efficacy in Blood Glucose Level Reduction in Diabetes, Journal of Isfahan Medical School (2009)
14. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
15. In Silico and in Vitro Studies of Thiosemicarbazone-Indole Hybrid Compounds As Potent Α-Glycosidase Inhibitors, Computational Biology and Chemistry (2022)
16. Glp-1-Based Therapies for Type 2 Diabetes: From Single, Dual and Triple Agonists to Endogenous Glp-1 Production and L-Cell Differentiation, Diabetology and Metabolic Syndrome (2025)
17. The Effects of Aqueous Extract of Alfalfa on Blood Glucose and Lipids in Alloxan-Induced Diabetic Rats, Interventional Medicine and Applied Science (2015)
18. Effect of Some High Consumption Spices on Hemoglobin Glycation, Indian Journal of Pharmaceutical Sciences (2014)
19. Anti-Oxidant Effect of Flavonoids on Hemoglobin Glycosylation, Pharmaceutica Acta Helvetiae (1999)
20. Enhancement of Anti-Diabetic Effects of Gliclazide Using Immediate Release Tablets in Streptozotocin-Induced Diabetic and Normal Rats, Farmacia (2013)
21. Possible Mechanisms and Molecular Signaling of Incretins Against the Development of Type 2 Diabetes Mellitus, Current Molecular Pharmacology (2023)
22. Inhibitory Potential of Pure Isoflavonoids, Red Clover, and Alfalfa Extracts on Hemoglobin Glycosylation, ARYA Atherosclerosis (2015)
23. Effects of Aqueous Extract of Alfalfa on Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Wistar Rats, Interventional Medicine and Applied Science (2016)
24. Identification of Polyphenolic Compounds Responsible for Antioxidant, Anti-Candida Activities and Nutritional Properties in Different Pistachio (Pistacia Vera L.) Hull Cultivars, Molecules (2023)
25. Effect of Ethanolic Extract of Juglans Regia L. on Blood Sugar in Diabetes-Induced Rats, Journal of Medicinal Food (2008)
26. Chemical Composition, Molecular Docking Analysis, and Biological Properties of Salvia Mirzayanii, Advanced Biomedical Research (2025)
27. Effects of Salvia Mirzayanii Extract Administration on Hyperglycemia Improvement in Diabetic Rats: The Role of Glut4, Pepck and G6pase Genes, Heliyon (2024)
28. Effect of Hydroalcoholic and Buthanolic Extract of Cucumis Sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats, Iranian Journal of Basic Medical Sciences (2011)
29. Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review, Advances in Experimental Medicine and Biology (2021)