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The Effects of Conjugated Linoleic Acid Supplementation on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis Publisher Pubmed



Asbaghi O1 ; Shimi G3 ; Naseri K4 ; Saadati S5 ; Kelishadi MR6 ; Doaei S7 ; Haghighat N8
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran
  4. 4. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia
  6. 6. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: European Journal of Pharmacology Published:2022


Abstract

Background: Findings of studies investigating the effect of conjugated linoleic acid (CLA) supplementation on blood pressure (BP) and endothelial function are controversial. Method: This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of CLA supplementation on BP and endothelial function. Two authors independently searched electronic databases using PubMed, Web of Science, and Scopus until March 2022, in order to find relevant RCTs. Results: Eighteen RCTs with 20 effect sizes met the inclusion criteria and were eligible for meta-analysis. CLA supplementation did not significantly alter systolic blood pressure (SBP) (WMD: -0.48; 95% CI: -3.23, 2.27), diastolic blood pressure (DBP) (WMD: -0.71; 95% CI: -3.54, 2.12), and vascular cell adhesion molecule (VCAM) (WMD: -34.02; 95% CI: -88.08, 20.03) levels. However, CLA supplementation significantly reduced intercellular adhesion molecule (ICAM) (WMD: -8.02; 95% CI: -13.95, −2.09) level. Conclusion: This systematic review and meta-analysis showed CLA association with reduction of ICAM. The PROSPERO registration number: CRD42022331108. © 2022 Elsevier B.V.
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