Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Imaging and Therapeutic Capabilities of the Aunps@Mnco3/Mn3o4, Coated With Paa and Integrated With Folic Acid, Doxorubicin and Propidium Iodide for Murine Breast Cancer Publisher



Arkaban H1 ; Karimi Shervedani R1 ; Yaghoobi F1 ; Kefayat A2 ; Ghahremani F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran
  2. 2. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Medical Physics and Radiotherapy, School of Paramedicine, Arak University of Medical Sciences, Arak, 38481-76941, Iran

Source: Journal of Drug Delivery Science and Technology Published:2022


Abstract

Targeted drug delivery systems have been designed to improve the efficiency of therapeutic and diagnostic agents. This strategy can also reduce the toxicity associated with these agents. Herein, a targeted imaging and therapeutic nanocomposite system, consisting of AuNPs double coated by MnCO3/Mn3O4 and polyacrylic acid, as CT-scan and MRI contrast agent, conjugated with folic acid, and loaded with doxorubicin and propidium iodide, as targeting, therapeutic and fluorescence agents, AuNPs@MnCO3/Mn3O4@PAA-FOA (Dox&PI)load, is reported. The performance of the system is supported by the following findings: (i) The MRI efficiency and pH sensitivity of the MnCO3/Mn3O4 nanocomposite supported by the MRI relaxation rates, 12.62 and 1.32 mM−1 s−1, obtained respectively at pHs of 5.5 and 7.4. (ii) The efficiency as well as the synergistic effect between the PI and AuNPs for enhancing the contrast of CT images revealed by the slopes of Hounsfield unit vs. system concentration, 23.22 and 32.63 HU L/g, obtained respectively for AuNPs@MnCO3/Mn3O4@PAA-FOA and AuNPs@MnCO3/Mn3O4@PAA-FOA (PI)load. (iii) The intracellular delivery shown by the cytometry and fluorescence results. (iv) The anticancer activity supported by effect of Doxloaded-system on the growth of tumors. (v) The biodistribution in the 4T1 breast tumor-bearing BALB/c mice supported by the elemental analysis of the organs by ICP-OES. (vi) The biocompatibility supported by blood biochemistry and histopathological examinations. The experimental results are presented and discussed to approve the above mentioned supports. © 2021 Elsevier B.V.
Related Docs
View other Related Docs
1. A Nanocomposite Theranostic System, Consisting of Aunps@Mnco3/Mn3o4 Coated With Paa and Integrated With Folic Acid, Doxorubicin, and Propidium Iodide: Synthesis, Characterization and Examination for Capturing of Cancer Cells, Inorganic Chemistry Communications (2021)
2. Therapeutic Effect of Deferrioxamine Conjugated to Pegylated Gold Nanoparticles and Complexed With Mn(Ii) Beside the Ct Scan and Mri Diagnostic Studies, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2019)
3. Fabrication of a Biocompatible & Biodegradable Targeted Theranostic Nanocomposite With Ph-Controlled Drug Release Ability, Journal of Drug Delivery Science and Technology (2022)
4. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
5. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
6. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
7. Folate-Graphene Chelate Manganese Nanoparticles As a Theranostic System for Colon Cancer Mr Imaging and Drug Delivery: In-Vivo Examinations, Journal of Drug Delivery Science and Technology (2019)
8. Highly Sensitive Mixed Molecular Nanostructures of Glutamine and Doxorubicin on Gold for Targeted Recognition of A2780 Cancer Cells Using Impedance Spectroscopy and Quartz Crystal Microbalance, Sensors and Actuators, B: Chemical (2021)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (25)
Mahboubeh Rostami (7)
Other Related Docs
9. The Physicochemical Behavior of Temozolomide Stabilized on Folic Acid−Targeted−Gold−Thiol Modified Surface Via Covalent Conjugation Towards Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2023)
10. Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review, ACS Applied Nano Materials (2022)
11. Recent Nanotheranostics Applications for Cancer Therapy and Diagnosis: A Review, IET Nanobiotechnology (2021)
12. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
13. Lignin, Lipid, Protein, Hyaluronic Acid, Starch, Cellulose, Gum, Pectin, Alginate and Chitosan-Based Nanomaterials for Cancer Nanotherapy: Challenges and Opportunities, International Journal of Biological Macromolecules (2021)
14. Eco-Friendly and Sustainable Synthesis of Biocompatible Nanomaterials for Diagnostic Imaging: Current Challenges and Future Perspectives, Green Chemistry (2020)
15. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
16. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and in Vitro Cytotoxicity Evaluations, Langmuir (2021)
17. Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6, Journal of Isfahan Medical School (2021)
18. Anderson-Type Manganese Polyoxomolybdate Hybrid Nanocomposite for Boosting Drug Delivery Against Breast Cancer, Journal of Drug Delivery Science and Technology (2023)
19. Synthesis and in Vitro Evaluation of Mr Molecular Imaging Probes Using J591 Mab-Conjugated Spions for Specific Detection of Prostate Cancer, Contrast Media and Molecular Imaging (2013)
20. Synthesis, Characterization and Mri Application of Cobalt-Zinc Ferrite Nanoparticles Coated With Dmsa: An In-Vivo Study, Applied Magnetic Resonance (2021)
21. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
22. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
23. Advanced Nanosystems for Cancer Therapeutics: A Review, ACS Applied Nano Materials (2023)
24. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
25. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
26. Cytotoxic Effects of Targeted Galactosylated Pluronic F127/Pluronicl122 Nano-Sized Micelles Loaded With Doxorubicin in Human Hepatocellular Carcinoma Cell Line, Journal of Isfahan Medical School (2013)
27. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
28. Superparamagnetic Iron Oxide Nanoparticle-Loaded Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging-Guided Drug Delivery, New Journal of Chemistry (2023)
29. Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments, Journal of Cancer Research and Clinical Oncology (2023)
30. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
31. Targeted Delivery of Doxorubicin to Breast Cancer Cells by Magnetic Lhrh Chitosan Bioconjugated Nanoparticles, International Journal of Biological Macromolecules (2016)
32. Mtx-Loaded Dual Thermoresponsive and Ph-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer, Molecular Pharmaceutics (2021)
33. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
34. Trastuzumab Conjugated Porphyrin-Superparamagnetic Iron Oxide Nanoparticle: A Potential Ptt-Mri Bimodal Agent for Herceptin Positive Breast Cancer, Photodiagnosis and Photodynamic Therapy (2020)
35. Functionalized Magnetic Nanoparticles for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices (2024)
36. Folic Acid-Functionalized Gadolinium-Loaded Phase Transition Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging of Hepatocellular Carcinoma, Talanta (2021)
37. Polyoxometalates As Next-Generation of Theragnostic Gadgets in Cancer, Reviews in Inorganic Chemistry (2024)
38. Magnetic Iron Oxide Nanoparticles As T2 Mr Imaging Contrast Agent for Detection of Breast Cancer (Mcf-7) Cell, Avicenna Journal of Medical Biotechnology (2017)
39. Recent Advances and Future Directions in Imaging of Peripheral Nervous System: A Comprehensive Review for Therapeutics Approach, Journal of Advances in Medical and Biomedical Research (2023)
40. Anti-Cd24 Bio Modified Pegylated Gold Nanoparticles As Targeted Computed Tomography Contrast Agent, Advanced Pharmaceutical Bulletin (2018)
41. Bevacizumab and Folic Acid Dual-Targeted Gadolinium-Carbon Dots for Fluorescence/Magnetic Resonance Imaging of Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2021)
42. Synthesis and Application of Fe3o4@Au Composite Nanoparticles As Magnetic Resonance/Computed Tomography Dual-Modality Contrast Agent, Journal of Medical Signals and Sensors (2020)
43. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
44. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
45. Assessment of Ploy Dopamine Coated Fe3o4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection, Anti-Cancer Agents in Medicinal Chemistry (2020)
46. Medical Imaging Modalities Using Nanoprobes for Cancer Diagnosis: A Literature Review on Recent Findings, Journal of Research in Medical Sciences (2019)
47. Study the Anti-Muc1 Antibody-Based Iron Oxide Nanoparticles on Three-Dimension Spheroid and Breast Cancer (Mcf-7) Cell Imaging, Polish Journal of Medical Physics and Engineering (2019)
48. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
49. Modified Bismuth Nanoparticles: A New Targeted Nanoprobe for Computed Tomography Imaging of Cancer, Cell Journal (2022)
50. Assessment of Manganese-Zinc Ferrite Nanoparticles As a Novel Magnetic Resonance Imaging Contrast Agent for the Detection of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)