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Ginkgo Biloba in the Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. a Randomized, Placebo-Controlled, Trial Publisher Pubmed



Shakibaei F1 ; Radmanesh M2 ; Salari E3 ; Mahaki B4
Authors
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Authors Affiliations
  1. 1. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Complementary Therapies in Clinical Practice Published:2015


Abstract

Objective: To evaluate the efficacy of Ginkgo biloba as a complementary therapy for attention-deficit/hyperactivity disorder (ADHD). Methods: Children and adolescents with ADHD received methylphenidate (20-30mg/day) plus either G.biloba (80-120mg/day) or placebo for 6 weeks. Parent and teacher forms of the ADHD Rating Scale-IV (ADHD-RS-IV) were completed at baseline, week 2, and week 6. Treatment response was defined as 27% improvement from baseline in the ADHD-RS-IV. Results: Compared with placebo, more reduction was observed with G.biloba regarding ADHD-RS-IV parent rating inattention score (-7.74±1.94 vs.-5.34±1.85, P<0.001) and total score (-13.1±3.36 vs.-10.2±3.01, P=0.001) as well as teacher rating inattention score (-7.29±1.90 vs.-5.96±1.52, P=0.004). Response rate was higher with G.biloba compared with placebo based on parent rating (93.5% vs. 58.6%, P=0.002). Conclusions: The G.biloba is an effective complementary treatment for ADHD. Further studies with longer treatment duration are warranted in this regard. IRCT2014111519958N1. © 2015 Elsevier Ltd.
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