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A Systematic Review of the Beneficial Effects of Prebiotics, Probiotics, and Synbiotics on Adhd Publisher Pubmed



Allahyari P1 ; Abbastorki S2 ; Aminnezhadkavkani B3 ; Mahmoudi Z3 ; Mousavihoseini MS4 ; Moradi M5 ; Alami F6 ; Keshavarzmohammadian M3 ; Bahooselebani S7 ; Abbasimobarakeh K8 ; Shafaei H9 ; Khoshdooz S9 ; Hajipour A10 ; Doaei S11 Show All Authors
Authors
  1. Allahyari P1
  2. Abbastorki S2
  3. Aminnezhadkavkani B3
  4. Mahmoudi Z3
  5. Mousavihoseini MS4
  6. Moradi M5
  7. Alami F6
  8. Keshavarzmohammadian M3
  9. Bahooselebani S7
  10. Abbasimobarakeh K8
  11. Shafaei H9
  12. Khoshdooz S9
  13. Hajipour A10
  14. Doaei S11
  15. Gholamalizadeh M12
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran
  2. 2. Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Clinical Psychology, Payame Noor University, Tehran, Iran
  6. 6. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  7. 7. Islamic Azad University, Roudehen Branch, Tehran, Iran
  8. 8. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Shahid Beheshti College of Midwifery, Gilan University of Medical Sciences, Rasht, Iran
  10. 10. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
  11. 11. Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Neuropsychopharmacology Reports Published:2024


Abstract

Background: Children with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted. Methods: The present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria. Results: Research on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health-related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels. Conclusion: The use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD. © 2024 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
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