Tehran University of Medical Sciences

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Faculty Members have conducted research related to the M2000 (Β-D-Mannuronic Acid) As a Novel Antagonist for Blocking the Tlr2 and Tlr4 Downstream Signalling Pathway
Farhad Gharibdoost
Farhad Gharibdoost

Professor of Rheumatology

Department Internal Medicine

School of Medicine

Shariati Hospital

Rheumatology Research Center

Tehran University of Medical Sciences

All Documents
1. Interferon-Γ Induces Interleukin-6 Production and Alpha-Smooth Muscle Actin Expression in Systemic Sclerosis Fibroblasts, Iranian Journal of Allergy# Asthma and Immunology (2024)
2. The Presence of Abnormal Septal Motion on Echocardiography Is a Predictor of Abnormal Cardiac Magnetic Resonance in Systemic Sclerosis, Rheumatology (United Kingdom) (2024)
3. Safety and Effectiveness of Septimebtm in Patients With Covid-19 Referred to a Teaching and Referral Hospital: An Uncontrolled Clinical Trial Study (Phase Ii), Journal of Iranian Medical Council (2023)
4. Translation and Validation of the Persian Version of the Scleroderma Health Assessment Questionnaire (Shaq), Internal and Emergency Medicine (2023)
5. Efficacy and Safety of The Biosimilar Denosumab Candidate (Arylia) Compared to the Reference Product (Prolia®) in Postmenopausal Osteoporosis: A Phase Iii, Randomized, Two-Armed, Double-Blind, Parallel, Active-Controlled, and Noninferiority Clinical Trial, Arthritis Research and Therapy (2022)
6. Efficacy and Safety of The Biosimilar Denosumab Candidate (Arylia) Compared to the Reference Product (Prolia®) in Postmenopausal Osteoporosis: A Phase Iii, Randomized, Two-Armed, Double-Blind, Parallel, Active-Controlled, and Noninferiority Clinical Trial, Arthritis Research and Therapy (2022)
7. A Phase Iv Study of the Safety and Efficacy of Cinnopar®In Iranian Patients With Osteoporosis, Journal of Osteoporosis (2021)
8. A Phase Iv Study of the Safety and Efficacy of Cinnopar®In Iranian Patients With Osteoporosis, Journal of Osteoporosis (2021)
9. Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (Asqa): A Multicenter Post-Marketing Surveillance Study, Advances in Therapy (2021)
10. Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (Asqa): A Multicenter Post-Marketing Surveillance Study, Advances in Therapy (2021)
11. Evaluation of Keratin 1 Gene Expression and Its Single Nucleotide Polymorphism (Rs14024) in Systemic Sclerosis Patients, Gene Reports (2021)
12. The Clinical Course of Covid-19 in Systemic Sclerosis Patients, Report From 150 Patients, Internal and Emergency Medicine (2021)
13. Assessment of Global Longitudinal Strain Via Speckle-Tracking Echocardiography in Patients With Rheumatoid Arthritis, Iranian Heart Journal (2020)
14. Cervical Cancer Screening and Pap Test Non-Adherence Risk Factors in Systemic Sclerosis Patients, European Journal of Cancer Prevention (2020)
15. Evaluation of the Association Between Kir Polymorphisms and Systemic Sclerosis: A Meta-Analysis, Advances in rheumatology (London# England) (2020)
16. Micrornas Are Potentially Regulating the Survivin Gene in Pbmcs From Systemic Sclerosis Patients, Modern Rheumatology (2020)
17. The Clinical Value of the Delta Finger to Palm Distance in Systemic Sclerosis, Reumatismo (2020)
18. Analysis of Gene Expression Profiles and Protein-Protein Interaction Networks in Multiple Tissues of Systemic Sclerosis, BMC Medical Genomics (2019)
19. Analysis of the Genetic Component of Systemic Sclerosis in Iranian and Turkish Populations Through a Genome-Wide Association Study, Rheumatology (United Kingdom) (2019)
20. Association Between Cd247 Gene Rs2056626 Polymorphism and the Risk of Systemic Sclerosis: Evidence From a Systematic Review and Bayesian Hierarchical Meta-Analysis, Meta Gene (2019)
21. Attenuation of Aquaporin-3 and Epidermal Growth Factor Receptor Expression and Activation in Systemic Sclerosis Dermal Fibroblasts, Journal of Cellular Physiology (2019)
22. Bundle Branch Blocks and Fragmented Qrs Complex in Iranian Patients With Systemic Sclerosis, Journal of Tehran University Heart Center (2019)
23. Comparison of the Clinical Phenotype of Systemic Sclerosis Patients in Iran and France in Two University Centers, Journal of Scleroderma and Related Disorders (2019)
24. Downregulation of Mir-542-3P Contributes to Apoptosis Resistance in Dermal Fibroblasts From Systemic Sclerosis Patients Via Survivin Overexpression, Iranian Journal of Allergy# Asthma and Immunology (2019)
25. Microrna-21 and Microrna-29A Modulate the Expression of Collagen in Dermal Fibroblasts of Patients With Systemic Sclerosis, Autoimmunity (2019)
26. Overexpression of Apoptosis-Related Protein, Survivin, in Fibroblasts From Patients With Systemic Sclerosis, Irish Journal of Medical Science (2019)
27. The Detection of Mycoplasma Spp. Dna in Synovial Fluid of Patients With Inflammatory Arthritis Using Pcr-Rflp, Infection# Epidemiology and Microbiology (2019)
28. A Phase I/Ii Randomized, Controlled, Clinical Trial for Assessment of the Efficacy and Safety of Β-D-Mannuronic Acid in Rheumatoid Arthritis Patients, Inflammopharmacology (2018)
29. Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs, Human Immunology (2018)
30. Evaluation of Itgb2 (Cd18) and Sell (Cd62l) Genes Expression and Methylation of Itgb2 Promoter Region in Patients With Systemic Sclerosis, Rheumatology International (2018)
31. Expressions of P53 and Puma in Fibroblasts of Systemic Sclerosis Patients Are Normal at Transcription Level, Journal of Cosmetic Dermatology (2018)
32. Expressions of P53 and Puma in Fibroblasts of Systemic Sclerosis Patients Are Normal at Transcription Level, Journal of Cosmetic Dermatology (2018)
33. Genetic Implications in the Pathogenesis of Systemic Sclerosis, International Journal of Rheumatic Diseases (2018)
34. Intra-Articular Knee Implantation of Autologous Bone Marrow–Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis Patients With Knee Involvement: Results of a Randomized, Triple-Blind, Placebo-Controlled Phase 1/2 Clinical Trial, Cytotherapy (2018)
35. Targeting of Circulating Th17 Cells by Β-D-Mannuronic Acid (M2000) As a Novel Medication in Patients With Rheumatoid Arthritis, Inflammopharmacology (2018)
36. A Phase Iii, Randomized, Two-Armed, Double-Blind, Parallel, Active Controlled, and Non-Inferiority Clinical Trial to Compare Efficacy and Safety of Biosimilar Adalimumab (Cinnora®) to the Reference Product (Humira®) in Patients With Active Rheumatoid Arthritis, Arthritis Research and Therapy (2017)
37. A Phase Iii, Randomized, Two-Armed, Double-Blind, Parallel, Active Controlled, and Non-Inferiority Clinical Trial to Compare Efficacy and Safety of Biosimilar Adalimumab (Cinnora®) to the Reference Product (Humira®) in Patients With Active Rheumatoid Arthritis, Arthritis Research and Therapy (2017)
38. Analysis of Killer Cell Immunoglobulin-Like Receptors (Kirs) and Their Hla Ligand Genes Polymorphisms in Iranian Patients With Systemic Sclerosis, Clinical Rheumatology (2017)
39. Association Study of Cd226 and Cd247 Genes Single Nucleotide Polymorphisms in Iranian Patients With Systemic Sclerosis, Iranian Journal of Allergy# Asthma and Immunology (2017)
40. Downregulation of Aquaporin3 in Systemic Sclerosis Dermal Fibroblasts, Iranian Journal of Allergy# Asthma and Immunology (2017)
41. Evaluation of Tlr9 Expression on Pbmcs and Cpg Odn-Tlr9 Ligation on Ifn-Α Production in Sle Patients, Immunopharmacology and Immunotoxicology (2017)
42. Hematological Improvement of Patients With Active Rheumatoid Arthritis by Β-D-Mannuronic Acid (M2000) As a Novel Nsaid With Immunosuppressive Property, Iranian Journal of Allergy# Asthma and Immunology (2017)
43. Irf7 Gene Expression Profile and Methylation of Its Promoter Region in Patients With Systemic Sclerosis, International Journal of Rheumatic Diseases (2017)
44. Prevalence and Severity of Depression and Anxiety in Patients With Systemic Sclerosis: An Epidemiologic Survey and Investigation of Clinical Correlates, Journal of Clinical Rheumatology (2017)
45. The Anti-Migraine Effects of M2000 (Β-D-Mannuronic Acid) on a Patient With Rheumatoid Arthritis: Case Report, Current Clinical Pharmacology (2017)
46. Comparison of the Expression Levels of Fas and Apaf-1 Genes in Systemic Sclerosis Dermal Fibroblasts, Tehran University Medical Journal (2016)
47. Comparison of the Expression Levels of Fas and Apaf-1 Genes in Systemic Sclerosis Dermal Fibroblasts, Tehran University Medical Journal (2016)
48. Inhibition of Microrna-21 Induces Apoptosis in Dermal Fibroblasts of Patients With Systemic Sclerosis, International Journal of Dermatology (2016)
49. Padi4 Polymorphisms in Iranian Patients With Rheumatoid Arthritis, Acta Reumatologica Portuguesa (2016)
50. Attenuation of Fibrosis With Selective Inhibition of C-Abl by Sirna in Systemic Sclerosis Dermal Fibroblasts, Archives of Dermatological Research (2015)
51. C-Abl Silencing Reduced the Inhibitory Effects of Tgf-Β1 on Apoptosis in Systemic Sclerosis Dermal Fibroblasts, Molecular and Cellular Biochemistry (2015)
52. Herbal Medicine Imod Suppresses Lps-Induced Production of Proinflammatory Cytokines in Human Dendritic Cells, Frontiers in Pharmacology (2015)
53. Il-1A Rs1800587, Il-1B Rs1143634 and Il-1R1 Rs2234650 Polymorphisms in Iranian Patients With Systemic Sclerosis, International Journal of Immunogenetics (2015)
54. Microrna-29A Induces Apoptosis Via Increasing the Bax:Bcl-2 Ratio in Dermal Fibroblasts of Patients With Systemic Sclerosis, Autoimmunity (2015)
55. Non-Corticosteroid Risk Factors of Symptomatic Avascular Necrosis of Bone in Systemic Lupus Erythematosus: A Retrospective Case-Control Study, Modern Rheumatology (2015)
56. Prevalence and Severity of Depression and Anxiety in Patients With Systemic Lupus Erythematosus: An Epidemiologic Study in Iranian Patients, Modern Rheumatology (2015)