Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Anticonvulsant Activity of 1,2,4-Triazine Derivatives With Pyridyl Side Chain: Synthesis, Biological, and Computational Study
Hamed Shafaroodi
Hamed Shafaroodi

Professor of Pharmacology

Department Pharmacology

School of Medicine

Tehran University of Medical Sciences

All Documents
1. Acute Anticonvulsant Effects of Dapsone on Ptz- and Mes-Induced Seizures in Mice: Nlrp3 Inflammasome Inhibition and Nrf2/Ho-1 Pathway Preservation, Pharmacological Reports (2025)
2. Aprepitant Mitigates Paclitaxel-Induced Neuropathic Pain in Rats Via Suppressing Inflammatory Pathways in Dorsal Root Ganglia, Drug and Chemical Toxicology (2025)
3. Ivermectin As a Promising Therapeutic Option for Onchocerciasis-Associated Epilepsy, Epilepsia Open (2025)
4. Protective Effects of Lithium Against Testicular Ischemia-Reperfusion Injury: Involvement of the Akt/Gsk-3Β Pathway, Journal of Pediatric Urology (2025)
5. Psilocin Alleviates Acute Itch in Mice: Possible Involvement of 5-Ht2a Receptors and Kynurenine Pathway, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
6. Psilocin, a Psychedelic Drug, Exerts Anticonvulsant Effects Against Ptz- and Mes-Induced Seizures in Mice Via 5-Ht1a and Cb1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways, Pharmacology Research and Perspectives (2025)
7. The Keap1/Nrf2/Are/Ho-1 Axis in Epilepsy: Crosstalk Between Oxidative Stress and Neuroinflammation, International Immunopharmacology (2025)
8. The Neuroprotective Effects of Hesperidin and Diosmin in Neurological Disorders Via Targeting Various Signaling Pathways, Iranian Journal of Basic Medical Sciences (2025)
9. Anticonvulsant Effects of Pentoxifylline on Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Male Mice: The Role of the Nitrergic Pathway, IBRO Neuroscience Reports (2024)
10. Effect of Micronized Purified Flavonoid Fraction Containing Hesperidin and Diosmin on Vincristine-Induced Neuropathy in Rats; the Role of Nitric Oxide Pathway, Iranian Journal of Pharmaceutical Research (2024)
11. Evaluating the Protective Effect of Dapsone on Experimental Osteoarthritis Models Induced by Mia in Male Rats, Journal of Pharmacy and Pharmacology (2024)
12. Investigating the Efficacy of Dapsone in Treating Sepsis Induced by Cecal Ligation and Puncture Surgery in Male Mice, Naunyn-Schmiedeberg's Archives of Pharmacology (2024)
13. Strategies to Reduce Neurotoxic Acrylamide in Biscuits, a Systematic Review, Toxicology Reports (2024)
14. Strategies to Reduce Neurotoxic Acrylamide in Biscuits, a Systematic Review, Toxicology Reports (2024)
15. Tyramine, a Biogenic Agent in Cheese: Amount and Factors Affecting Its Formation, a Systematic Review, Food Production, Processing and Nutrition (2024)
16. The Effect of Residual Antibiotics in Food on Intestinal Microbiota: A Systematic Review, Frontiers in Sustainable Food Systems (2023)
17. Aripiprazole Prevents Renal Ischemia/Reperfusion Injury in Rats, Probably Through Nitric Oxide Involvement, European Journal of Pharmacology (2017)
18. Novel Derivatives of Phthalimide With Potent Anticonvulsant Activity in Ptz and Mes Seizure Models, Iranian Journal of Basic Medical Sciences (2017)
19. Atorvastatin Attenuates the Antinociceptive Tolerance of Morphine Via Nitric Oxide Dependent Pathway in Male Mice, Brain Research Bulletin (2016)
20. Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice, Iranian Journal of Pharmaceutical Research (2016)
21. Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach, Current Pharmaceutical Design (2016)
22. Synthesis, Conformational Assignment, and Anti-Inflammatory Activities of N-Arylidene-2-(4-Chloro-2-(2-Substituted Phenoxy)Phenyl)Acetic Acid Hydrazides, Medicinal Chemistry Research (2016)
23. The Interaction Between Morphine and Propranolol in Chemical and Electrical Seizure Models of Mice, Neurological Research (2016)
24. Increased Salivary Nitrite and Nitrate Excretion in Rats With Cirrhosis, Acta Medica Iranica (2015)
25. The Effects of Sub-Chronic Treatment With Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway, Acta Medica Iranica (2015)
26. The Influence of Ovariectomy on Anti-Convulsant Effect of Pioglitazone in Mice, Pathophysiology (2015)
27. Design, Synthesis, and Calcium Channel Antagonist Activity of New 1,4-Dihydropyridines Containing 4-(5)-Chloro-2-Ethyl-5-(4)-Imidazolyl Substituent, Archiv der Pharmazie (2006)