Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Opioidergic and Nitrergic Systems Mediate the Anticonvulsant Effect of Mefloquine and Chloroquine on Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice
Raziyeh Mohammad Jafari
Raziyeh Mohammad Jafari

Assistant Professor of Pharmacology

Experimental Medicine Research Center

Tehran University of Medical Sciences

All Documents
1. Acute Anticonvulsant Effects of Dapsone on Ptz- and Mes-Induced Seizures in Mice: Nlrp3 Inflammasome Inhibition and Nrf2/Ho-1 Pathway Preservation, Pharmacological Reports (2025)
2. Anticonvulsant Effects of Noscapine Against Status Epilepticus Induced by Lithium-Pilocarpine in Rats: Involvement of Nrf2/Ho-1 and Nlrp3 Pathways, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
3. Ivermectin As a Promising Therapeutic Option for Onchocerciasis-Associated Epilepsy, Epilepsia Open (2025)
4. Lasmiditan Ameliorates Serotonergic Itch in Mice: Possible Involvement of 5-Ht1f Receptors, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
5. Protective Effects of Lithium Against Testicular Ischemia-Reperfusion Injury: Involvement of the Akt/Gsk-3Β Pathway, Journal of Pediatric Urology (2025)
6. Protective Effects of Sumatriptan Against Optic Nerve Injury in Rats Via Modulation of Kynurenine Pathway, Oxidative Stress and Apoptosis, BioImpacts (2025)
7. Psilocin Alleviates Acute Itch in Mice: Possible Involvement of 5-Ht2a Receptors and Kynurenine Pathway, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
8. Psilocin, a Psychedelic Drug, Exerts Anticonvulsant Effects Against Ptz- and Mes-Induced Seizures in Mice Via 5-Ht1a and Cb1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways, Pharmacology Research and Perspectives (2025)
9. Repurposing of Modafinil As an Anti-Inflammatory Drug: A Systematic Review of Experimental Studies, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
10. The Keap1/Nrf2/Are/Ho-1 Axis in Epilepsy: Crosstalk Between Oxidative Stress and Neuroinflammation, International Immunopharmacology (2025)
11. Evaluation Acute and Sub-Chronic Toxicity Assessments of Oleo-Gum Resin of Ferula Assa-Foetida L. in Wistar Rats, Journal of Medicinal Plants (2024)
12. Exploring the Therapeutic Potential of Modafinil in Mitigating Renal Ischemia–Reperfusion Injury in Rats, Fundamental and Clinical Pharmacology (2024)
13. From Dyes to Drugs: The Historical Impact and Future Potential of Dyes in Drug Discovery, Archiv der Pharmazie (2024)
14. Ivermectin Ameliorates Bleomycin-Induced Lung Fibrosis in Male Rats by Inhibiting the Inflammation and Oxidative Stress, Immunopharmacology and Immunotoxicology (2024)
15. Ivermectin Exerts Anticonvulsant Effects Against Status Epilepticus Induced by Lithium-Pilocarpine in Rats Via Gabaa Receptor and Neuroinflammation Modulation: Possible Interaction of Opioidergic Pathways and Katp Channel With Nitrergic System, Molecular Neurobiology (2024)
16. Phosphatidylserine Topically Attenuates Imiquimod-Induced Psoriasis Through Inflammation Inhibition in Mice, Drug Research (2024)
17. Protective Effects of Licofelone on Scopolamine-Induced Spatial Learning and Memory Impairment by Enhancing Parkin-Dependent Mitophagy and Promotion of Neural Regeneration and in Adult Mice, European Journal of Pharmacology (2024)
18. Spermidine Exerts Protective Effects in Random-Pattern Skin Flap Survival in Rats: Possible Involvement of Inflammatory Cytokines, Nitric Oxide, and Vegf, Aesthetic Plastic Surgery (2024)
19. Tirzepatide Outcompetes Long-Acting Insulin in Managing Type 2 Diabetes: A Meta-Analysis of Three Phase 3 Randomized Controlled Trials, International Journal of Obesity (2024)
20. Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa?, Contemporary Clinical Neuroscience (2023)
21. Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (Cb1), But Not Cb2 and Gabaa Receptors, Cannabis and Cannabinoid Research (2023)
22. Cannabidiol Improves Random-Pattern Skin Flap Survival in Rats: Involvement of Cannabinoid Type-2 Receptors, Journal of Reconstructive Microsurgery (2023)
23. Corrigendum to “Dual Drug Delivery System of Plga Nanoparticles to Reverse Drug Resistance by Altering Bax/Bcl-2” [J. Drug Deliv. Sci. Technol. 47 (2018) 291–298, (S1773224718301825), (10.1016/J.Jddst.2018.07.019)], Journal of Drug Delivery Science and Technology (2023)
24. Desmopressin Enhances Random-Pattern Skin Flap Survival in Rats: Possible Role of Vasopressin Type-1A and 2 Receptors, European Journal of Pharmacology (2023)
25. Development and Application of Prototype System Based on Light-Emitting Diode Arrays (660 Nm) With a Top Hat Beam Profile in Order to Optimize Photobiomodulation Protocols for Treatment of Radiation-Induced Oral Mucositis in Rats, Photobiomodulation# Photomedicine# and Laser Surgery (2023)
26. Functional Roles of Lncrnas in Recurrent Pregnancy Loss: A Review Study, International Journal of Fertility and Sterility (2023)
27. Investigating the Effect of Serotonin Ii and Iii Receptor Inhibitors on the Chronotropic Changes of the Heart to Isoproterenol in Rat Models of Biliary Cirrhosis, Acta Medica Iranica (2023)
28. Low-Dose Sumatriptan Improves the Outcome of Acute Mesenteric Ischemia in Rats Via Downregulating Kynurenine, Pharmacological Reports (2023)
29. Mechanisms Underlying Dose-Limiting Toxicities of Conventional Chemotherapeutic Agents, Journal of Chemotherapy (2023)
30. Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice, Neurochemical Research (2023)
31. The Current State of Knowledge on How to Improve Skin Flap Survival: A Review, Journal of Plastic# Reconstructive and Aesthetic Surgery (2023)
32. The Possible Protective Effects of Ondansetron and Tropisetron on Optic Nerve Crush Injury in Rats, Drug Research (2023)
33. Therapeutic Potential of Bromhexine for Acute Itch in Mice: Involvement of Tmprss2 and Kynurenine Pathway, International Immunopharmacology (2023)
34. Anti-Inflammatory Effects of Ivermectin in the Treatment Of Acetic Acid-Induced Colitis in Rats: Involvement of Gabab Receptors, Digestive Diseases and Sciences (2022)
35. Anticonvulsant Effects of Ivermectin on Pentylenetetrazole- and Maximal Electroshock-Induced Seizures in Mice: The Role of Gabaergic System and Katp Channels, Heliyon (2022)
36. Ion-Pair Hollow Fiber Liquid-Phase Microextraction Combined With Capillary Electrophoresis for the Determination of Biogenic Amines in Rat Tissues, Journal of Pharmaceutical and Biomedical Analysis (2022)
37. Opioidergic and Nitrergic Systems Mediate the Anticonvulsant Effect of Mefloquine and Chloroquine on Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice, Acta Neurobiologiae Experimentalis (2022)
38. Sildenafil Improves Radiation-Induced Oral Mucositis by Attenuating Oxidative Stress, Nf-Κb, Erk and Jnk Signalling Pathways, Journal of Cellular and Molecular Medicine (2022)
39. Sodium Selenite Modulates Ido1/ Kynurenine, Tlr4, Nf-Κb and Bcl2/Bax Pathway and Mitigates Acetic Acid- Induced Colitis in Rat, Cellular Physiology and Biochemistry (2022)
40. The N-Methyl-D-Aspartate Receptor Antagonist Ketamin Exerts Analgesic Effects Via Modulation of the Nitric Oxide Pathway, Fundamental and Clinical Pharmacology (2022)
41. The Promising Effect of Colchicine on Random-Pattern Skin Flap Survival in Rats: Glutamate Pathway, Journal of Surgical Research (2022)
42. The Protective Effect of Α7-Nach Receptor and Its Interaction With 5-Ht1b/1D Receptors in Acute Intestinal Ischemia-Reperfusion Injury in Rats, Fundamental and Clinical Pharmacology (2022)
43. Aquaporins and Diseases Pathogenesis: From Trivial to Undeniable Involvements, a Disease-Based Point of View, Journal of Cellular Physiology (2021)
44. Beyond Its Anti-Migraine Properties, Sumatriptan Is an Anti-Inflammatory Agent: A Systematic Review, Drug Development Research (2021)
45. Dapsone Ameliorates Colitis Through Tlr4/Nf-Kb Pathway in Tnbs Induced Colitis Model in Rat, Archives of Medical Research (2021)
46. Ivermectin Increases Random-Pattern Skin Flap Survival in Rats: The Novel Role of Gabaergic System, Journal of Surgical Research (2021)
47. Licofelone, a Potent Cox/5-Lox Inhibitor and a Novel Option for Treatment of Neurological Disorders, Prostaglandins and Other Lipid Mediators (2021)
48. Neuroprotective Effect of Intravitreal Single-Dose Lithium Chloride After Optic Nerve Injury in Rats, Current Eye Research (2021)
49. Protective Effect of Modafinil on Skin Flap Survival in the Experimental Random-Pattern Skin Flap Model in Rats: The Role of Atp-Sensitive Potassium Channels and Nitric Oxide Pathway, Journal of Plastic# Reconstructive and Aesthetic Surgery (2021)
50. Sildenafil Beyond Erectile Dysfunction and Pulmonary Arterial Hypertension: Thinking About New Indications, Fundamental and Clinical Pharmacology (2021)
51. Treatment Parameters of Photobiomodulation in the Prevention of Non-Surgical Cancer Treatment-Induced Oral Mucositis: A Review of Preclinical Studies, Journal of Lasers in Medical Sciences (2021)
52. Cuminum Cyminum Fruits As Source of Luteolin- 7-O-Glucoside, Potent Cytotoxic Flavonoid Against Breast Cancer Cell Lines, Natural Product Research (2020)
53. Diabetes Mellitus and Osteoporosis Correlation: Challenges and Hopes, Current Diabetes Reviews (2020)
54. Does Pharmacodynamics of Drugs Change After Presenting Them As Na-Noparticles Like Their Pharmacokinetics?, Current Drug Targets (2020)
55. Effect of Hydroxychloroquine on Prevention of Covid-19 Virus Infection Among Healthcare Professionals: A Structured Summary of a Study Protocol for a Randomised Controlled Trial, Trials (2020)
56. Evaluation of the Role of Tlr4 in Endotoxin-Induced Hepatic Encephalopathy in Rats With Biliary Cirrhosis, Tehran University Medical Journal (2020)
57. Involvement of 5-Ht1b/1D Receptors in the Inflammatory Response and Oxidative Stress in Intestinal Ischemia/Reperfusion in Rats, European Journal of Pharmacology (2020)
58. Sodium Valproate Improves Skin Flap Survival Via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System, Journal of Surgical Research (2020)
59. Sumatriptan Alleviates Radiation-Induced Oral Mucositis in Rats by Inhibition of Nf-Kb and Erk Activation, Prevention of Tnf-Α and Ros Release, Archives of Oral Biology (2020)
60. Evaluation of Isolated Vascular Response to 5Ht1a, 5Ht1b1d & 5Ht2a Receptors Agonist & Antagonist in Chronic Endotoxemic Rats, Drug Research (2019)
61. The Antidepressant Effects of Gm-Csf Are Mediated by the Reduction of Tlr4/Nf-Kb-Induced Ido Expression, Journal of Neuroinflammation (2019)
62. Drug Repositioning: A Review, Journal of Iranian Medical Council (2018)
63. Dual Drug Delivery System of Plga Nanoparticles to Reverse Drug Resistance by Altering Bax/Bcl-2, Journal of Drug Delivery Science and Technology (2018)
64. The Anticonvulsant Activity and Cerebral Protection of Chronic Lithium Chloride Via Nmda Receptor/Nitric Oxide and Phospho-Erk, Brain Research Bulletin (2018)
65. Genistein Modulation of Seizure: Involvement of Estrogen and Serotonin Receptors, Journal of Natural Medicines (2017)