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Evaluation Acute and Sub-Chronic Toxicity Assessments of Oleo-Gum Resin of Ferula Assa-Foetida L. in Wistar Rats



Tofighi Z1, 2 ; Jafari RM3 ; Besati M4 ; Hamedani MP2 ; Hadjiakhoondi A1, 2 ; Baharipour Z5 ; Jariani A2 ; Moiin Z2 ; Tavakoli S6 ; Goodarzi S1
Authors
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Authors Affiliations
  1. 1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
  5. 5. School of Pharmacy, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  6. 6. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran

Source: Journal of Medicinal Plants Published:2024

Abstract

Background: Ferula assa-foetida is an herbaceous plant from Apiaceae family. Several pharmacological effects of oleo-gum resin of this plant were introduced in modern and traditional medicines such as digestive, antimicrobial, anti-diabetic, appetizing, insecticidal, and etc. Objectives: This study aimed to acute and sub-chronic toxicity of chloroform fraction of oleo-gum extract of Ferula in Wistar rats. The safety of this can guarantee its use in treatment and various industries. Methods: Rats in six groups including male and female (kept separately) at different doses (50 mg/kg, 500 mg/kg, and 2000 mg/kg) and two control groups (control and DMSO(were selected to evaluate the acute toxicity of chloroform fraction of Ferula. For 30 days, 50 mg/kg and 250 mg/kg of sample was administrated to male and female rats. Mortality, appearance and behavioral changes, food intake, the weight of rats, and hematological, biochemical variables and histopathological changes were examined. Results: Physical and behavioral changes were not observed in acute and sub-chronic toxicity conditions. Food intake significantly differed between male and female DMSO control and other groups. In biochemical variables study, only SGOT (AST) showed a significant difference from the control group (DMSO) in acute toxicity and BUN, ALP and SGOT (AST) in sub-chronic toxicity. Also, any histopathological change was observed in spleen, liver, and kidney organs. Conclusion: Oleo-gum resin of F. assa-foetida has not toxic effects, so it should be used with caution in the long term. © 2023. Open access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/)