Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Investigation of Mdma Inhibitory Effect on Cytochrome P450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol
Yalda Hosseinzadeh Ardakani
Yalda Hosseinzadeh Ardakani

Associate Professor of Pharmaceutics

Department Pharmaceutics

School of Pharmacy

Personalized Medicine Research Center

Endocrinology and Metabolism Research Institute

Tehran University of Medical Sciences

All Documents
1. Expression, Purification, and Biological Evaluation of Xten-Gcsf in a Neutropenic Rat Model, Applied Biochemistry and Biotechnology (2024)
2. Evaluation of Important Human Cyp450 Isoforms and P-Glycoprotein Phenotype Changes and Genotype in Type 2 Diabetic Patients, Before and After Intensifying Treatment Regimen Using Geneva Cocktail, Basic and Clinical Pharmacology and Toxicology (2023)
3. Fundamentals and Applications of Isolated Perfused Lung (Ipl) Model in the Development of Pulmonary Drug Delivery, Current Drug Delivery (2023)
4. Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach, Journal of Personalized Medicine (2023)
5. Metabolic Modeling-Based Drug Repurposing in Statin: An Overview of Mechanistic Approaches in the Management of Craniocerebral Trauma, Journal of Cellular and Molecular Anesthesia (2023)
6. A Repurposed Drug Screen for Regulating Metabolic Disease: An Overview in the Management of Traumatic Brain Injury; [Una Deteccion De Drogas Reutilizada Para Regular La Enfermedad Metabolica: Una Descripcion General En El Manejo De La Lesion Cerebral Traumatica], Revista Latinoamericana de Hipertension (2022)
7. Enzyme and Thermo Dual-Stimuli Responsive Dox Carrier Based on Pnipam Conjugated Mesoporous Silica, Iranian Journal of Pharmaceutical Research (2022)
8. Study the Effect of 3,4-Methylenedioxy Methamphetamine on Cytochrome P450 2E1 Activity, Brazilian Journal of Pharmaceutical Sciences (2022)
9. Synthesis of Hyaluronic Acid-Grafted Hollow Mesoporous Silica Nanoparticles As Nano-Carriers for Anticancer Drug Delivery, Journal of Nanoparticle Research (2022)
10. Variations in the Frequencies of Polymorphisms in the Cyp450s Genes in Eight Major Ethnicities of Iran: A Review of the Human Data, Journal of Personalized Medicine (2022)
11. A Comparative Pharmacokinetic Study of a Novel Sustained Release Danofloxacin Formulation and the Conventional Product in Rabbits, Veterinary Research Forum (2021)
12. Evaluation of Cinnamon (Cinnamomum Verum) Effects on Liver Cyp450 2D1 Activity and Hepatic Clearance in Diabetic Rats, Jundishapur Journal of Natural Pharmaceutical Products (2021)
13. Evaluation of Phenoconversion Phenomenon in Obese Patients: The Effects of Bariatric Surgery on the Cyp450 Activity “A Protocol for a Case–Control Pharmacokinetic Study”, Journal of Diabetes and Metabolic Disorders (2021)
14. Evaluation of the Association Between Trough and Area Under the Curve to Minimum Inhibitory Concentration Ratio (Auc24/Mic) of Vancomycin in Infected Patients With Methicillin Resistant Staphylococcus Aureus (Mrsa), Pharmaceutical Sciences (2021)
15. Frequency of Important Cyp450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison With Other Major Populations: A Comprehensive Review of the Human Data, Journal of Personalized Medicine (2021)
16. Hollow Mesoporous Silica Nanoparticles for Co-Delivery of Hydrophobic and Hydrophilic Molecules: Mechanism of Drug Loading and Release, Journal of Nanoparticle Research (2021)
17. Investigation of Mdma Inhibitory Effect on Cytochrome P450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol, Advanced Pharmaceutical Bulletin (2021)
18. Sn38 Loaded Nanostructured Lipid Carriers (Nlcs); Preparation and in Vitro Evaluations Against Glioblastoma, Journal of Materials Science: Materials in Medicine (2021)
19. Subcutaneous After Enrofloxacin of Pharmacokinetics Comparative a and Preparation Forming Gel Situ in Novel a of Administration Rabbits to Product Conventional, Iranian Journal of Veterinary Medicine (2021)
20. Dose Concentration and Spatial Memory and Brain Mitochondrial Function Association After 3,4-Methylenedioxymethamphetamine (Mdma) Administration in Rats, Archives of Toxicology (2020)
21. Effect of 3,4-Methylenedioxymethamphetamine on Liver Cyp2c19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe, Journal of Mazandaran University of Medical Sciences (2020)
22. Evaluating the Effect of Type 2 Diabetes Mellitus on Cyp450 Enzymes and P-Gp Activities, Before and After Glycemic Control: A Protocol for a Case–Control Pharmacokinetic Study, MethodsX (2020)
23. Evaluation of Changes in Cytochrome P450 2C19 Activity in Type 2 Diabetic Rats Before and After Treatment, by Using Isolated Perfused Liver Model, Iranian Journal of Basic Medical Sciences (2020)
24. Evaluation of Hepatic Cyp2d1 Activity and Hepatic Clearance in Type I and Type Ii Diabetic Rat Models, Before and After Treatment With Insulin and Metformin, DARU# Journal of Pharmaceutical Sciences (2020)
25. Pharmacokinetic Changes of Tramadol in Rats With Hepatotoxicity Induced by Ethanol and Acetaminophen in Perfused Rat Liver Model, Alcohol (2019)
26. Assessment of Cyp2d6 Re-Activation After Inhibitory Effect of Mdma Using Tramadol As a Probe, Drug Metabolism and Personalized Therapy (2018)
27. Changes in Cyp2d Enzyme Activity Following Induction of Type 2 Diabetes, and Administration of Cinnamon and Metformin: An Experimental Animal Study, Xenobiotica (2018)
28. Gender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to Cyp2d6 Phenotype in Iranian Population, Iranian Journal of Pharmaceutical Research (2018)
29. Simultaneous Electrochemical Determination of Isoniazid and Ethambutol Using Poly-Melamine/Electrodeposited Gold Nanoparticles Modified Pre-Anodized Glassy Carbon Electrode, Ionics (2018)
30. A Disposition Kinetic Study of Tramadol in Bile Duct Ligated Rats in Perfused Rat Liver Model, Biomedicine and Pharmacotherapy (2017)
31. Evaluation of the Ecstasy Influence on Tramadol and Its Main Metabolite Plasma Concentration in Rats, Drug Metabolism and Personalized Therapy (2017)
32. Fabrication of a Novel Aptasensor Based on Three-Dimensional Reduced Graphene Oxide/Polyaniline/Gold Nanoparticle Composite As a Novel Platform for High Sensitive and Specific Cocaine Detection, Analytica Chimica Acta (2017)
33. Inhibition of Mirtazapine Metabolism by Ecstasy (Mdma) in Isolated Perfused Rat Liver Model, DARU# Journal of Pharmaceutical Sciences (2017)
34. Sensitive Electrochemical Determination of Rifampicin Using Gold Nanoparticles/Poly-Melamine Nanocomposite, RSC Advances (2017)
35. Assays for Mdma and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse (2016)
36. Assays for Mdma and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants# Club and Dissociative Drugs# Hallucinogens# Steroids# Inhalants and International Aspects (2016)
37. Assays for Tramadol and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse Volume 3: General Processes and Mechanisms# Prescription Medications# Caffeine and Areca# Polydrug Misuse# Emerging Addictions and Non-Drug Addictions (2016)
38. Fabrication of an Electrochemical Sensor Based on Magnetic Multi-Walled Carbon Nanotubes for the Determination of Ciprofloxacin, Analytical Methods (2016)
39. Imatinib Metabolism and Disposition in Isolated Rat Perfused Liver, Iranian Journal of Pharmaceutical Sciences (2016)
40. Modified Fractal Iron Oxide Magnetic Nanostructure: A Novel and High Performance Platform for Redox Protein Immobilization, Direct Electrochemistry and Bioelectrocatalysis Application, Biosensors and Bioelectronics (2016)