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Various Effects of Omega 3 and Omega 3 Plus Vitamin E Supplementations on Serum Glucose Level and Insulin Resistance in Patients With Coronary Artery Disease



Saboori S1, 2 ; Djalali M1 ; Yousefi Rad E3 ; Nematipour E4 ; Sabooryaraghi AA1 ; Javanbakht MH1 ; Eshraghian MR5 ; Ramezani A6 ; Koohdani F1, 7
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Authors Affiliations
  1. 1. Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  3. 3. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Dept. of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Dept. of Basic Sciences and Nutrition, Cardiovascular Research Center, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2016

Abstract

Background: Omega 3 and vitamin E are two critical nutrients which include beneficial effects in coronary artery disease (CAD). The aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin E on serum glucose and lipid levels and insulin resistance in CAD patients. Methods: Participants of this clinical trial included 60 male patients with CAD who selected from Tehran Heart Center in Tehran, Iran in 2014. They received 4 g/day omega 3 plus 400 IU/day vitamin E (OE), 4 g/day omega 3 with vitamin E placebo (OP), or omega 3 and vitamin E placebo (PP) for two months. Serum glucose, lipids and insulin were assessed and HOMA-IR was calculated before and after the trial and effects of these nutrients on the highlighted parameters were compared within the study groups. Results: Serum glucose level increased significantly in OP group (P=0.004), but not in OE group. OE and OP groups showed a significant decrease in fasting serum TG (P=0.020 and P=0.001, respectively). Serum insulin and HOMA-IR decreased significantly in OE group (P=0.044 and P=0.039, respectively) but did not change significantly in OP group. Conclusion: Although, omega 3 supplementation may include adverse effects on serum glucose level, co-administration of omega 3 and vitamin E can beneficially decrease serum insulin and insulin resistance in CAD patients. © 2016 Iranian Journal of Public Health. All rights reserved.
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