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Effects of Zinc Supplementation on Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Asbaghi O1, 2 ; Sadeghian M3, 4 ; Fouladvand F2 ; Panahande B5 ; Nasiri M6, 7 ; Khodadost M8, 9 ; Shokri A10 ; Pirouzi A1 ; Sadeghi O11, 12
Authors
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Authors Affiliations
  1. 1. Gerash University of Medical Sciences, Gerash, Iran
  2. 2. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
  5. 5. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Operating Room Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  11. 11. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Nutrition# Metabolism and Cardiovascular Diseases Published:2020


Abstract

Background and aim: Findings on the effects of zinc supplementation on the lipid profile in patients with type 2 diabetes mellitus (T2DM) are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard. Methods and results: After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of zinc supplementation on lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] in patients with T2DM. Altogether, 9 studies with a total sample size of 424 patients with T2DM were included in the analysis. Combining 9 effect sizes from 9 RCTs, we found a significant lowering effect of zinc supplementation on serum levels of TG (weighted mean difference (WMD): −17.08, 95% CI: −30.59, −3.58 mg/dL, P = 0.01) and TC (WMD: −26.16, 95% CI: −49.69, −2.62 mg/dL, P = 0.02). Although the overall effect of zinc supplementation on LDL-C levels was not significant, a beneficial effect was seen in studies that administered <100 mg/d zinc. Based on the non-linear dose–response analysis, a greater reduction in serum levels of TC and LDL-C following zinc supplementation was seen at <12 weeks’ duration of intervention. Unlike the overall effect size, we found a significant increasing effect of zinc supplementation on serum HDL-C concentrations in most subgroups of RCTs according to the subgroup analyses. Conclusion: We found that zinc supplementation may beneficially influence lipid profile in patients with T2DM. © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
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