Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents

Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents Publisher

Nourmahammadi J¹ ; Moghadam ES¹ ; Shahsavari Z² ; Amini M¹

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1. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
2. Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Letters in Organic Chemistry Published:2020

Abstract

Cancer is one of the major causes of mortality all around the world. Globally, nearly 1 in 6 deaths is due to cancer. Researchers are trying to synthesize new anticancer agents. Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. Herein, ten novel derivatives of 1,5-diarylpyrazole were synthesized in four step reactions and cytotoxic activity was investigated by MTT cell viability assay. All of the compounds were characterized by1H NMR and13C NMR and their purity was confirmed by elemental analysis. The cytotoxicity was determined against three cancerous cell lines (HT-29, U87MG and MDA-MB 468) and AGO1522 as a normal cell line. Compound 5a showed the best cytotoxic activity on cancerous cell lines in comparison to paclitaxel. Annexin V/ PI staining assay also showed that compounds 5a and 5i would lead to significant apoptosis induction in MDA-MB 486 cell line. © 2020 Bentham Science Publishers.

Style	Citing Format
MLA	Nourmahammadi J, et al.. "Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents." Letters in Organic Chemistry, vol. 17, no. 3, 2020, pp. 216-223.
APA	Nourmahammadi J, Moghadam ES, Shahsavari Z, Amini M (2020). Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents. Letters in Organic Chemistry, 17(3), 216-223.
Chicago	Nourmahammadi J, Moghadam ES, Shahsavari Z, Amini M. "Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents." Letters in Organic Chemistry 17, no. 3 (2020): 216-223.
Harvard	Nourmahammadi J et al. (2020) 'Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents', Letters in Organic Chemistry, 17(3), pp. 216-223.
Vancouver	Nourmahammadi J, Moghadam ES, Shahsavari Z, Amini M. Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents. Letters in Organic Chemistry. 2020;17(3):216-223.
BibTex	@article{ author = {Nourmahammadi J and Moghadam ES and Shahsavari Z and Amini M}, title = {Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents}, journal = {Letters in Organic Chemistry}, volume = {17}, number = {3}, pages = {216-223}, year = {2020} }
RIS	TY - JOUR AU - Nourmahammadi J AU - Moghadam ES AU - Shahsavari Z AU - Amini M TI - Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives As Anticancer Agents JO - Letters in Organic Chemistry VL - 17 IS - 3 SP - 216 EP - 223 PY - 2020 ER -

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