Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles

Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles Publisher

Salimi M^{1, 2} ; Sarkar S^{1, 2} ; Saber R^{2, 3} ; Delavari H⁴ ; Alizadeh AM⁵ ; Mulder HT⁶

Show Affiliations

1. Tehran University of Medical Sciences, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, P.O. Box 1417613151, Tehran, Iran
2. Tehran University of Medical Sciences, Research Center for Science and Technology in Medicine, Tehran, Iran
3. Tehran University of Medical Sciences, Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran, Iran
4. Tarbiat Modares University, Department of Materials Science and Engineering, Tehran, Iran
5. Tehran University of Medical Sciences, Cancer Research Center, Tehran, Iran
6. Erasmus Medical Center Cancer Institute, Department of Radiation Oncology, Rotterdam, Netherlands

Source: Cancer Nanotechnology Published:2018

Abstract

Background: Recently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or a vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates for coating iron-oxide nanoparticles which are applied in magnetic hyperthermia. To the best of our knowledge, the novelty of this study is the investigation of fourth-generation dendrimer-coated iron-oxide nanoparticles (G4@IONPs) in magnetic hyperthermia and MRI. Methods: IONPs were synthesized via co-precipitation and coated with the fourth generation (G4) of polyamidoamine dendrimer. The cytotoxicity of G4@IONPs with different concentrations was assessed in a human breast cancer cell line (MCF7) and human fibroblast cell line (HDF1). Hemolysis and stability of G4@IONPs were investigated, and in addition, the interaction of these particles with MCF7 cells was assessed by Prussian blue staining. Heat generation and specific absorption rate (SAR) were calculated from measurement and simulation results at 200 and 300kHz. MCF7 and HDF1 cells were incubated with G4@IONPs for 2h and then put into the magnetic coil for 120min. Relaxometry experiments were performed with different concentrations of G4@IONPs with T1- and T2-weighted MR images. Results: The TEM results showed that G4@IONPs were 10±4nm. The in vitro toxicity assessments showed that synthesized nanoparticles had low toxicity. The viability of MCF7 cells incubated with G4@IONPs decreased significantly after magnetic hyperthermia. In addition, MR imaging revealed that G4@IONPs improved transverse relaxivity (r2) significantly. Conclusions: Our results encouraged the future application of G4@IONPs in magnetic hyperthermia and MR imaging. © 2018 The Author(s).

Related Docs

View other Related Docs

1. Biodistribution, Pharmacokinetics, and Toxicity of Dendrimer-Coated Iron Oxide Nanoparticles in Balb/C Mice, International Journal of Nanomedicine (2018)

2. Treatment of Breast Cancer-Bearing Balb/C Mice With Magnetic Hyperthermia Using Dendrimer Functionalized Iron-Oxide Nanoparticles, Nanomaterials (2020)

3. The Effects of Peptide If7-Conjugated Dendrimer Loaded With Doxorubicin on Colorectal Cancer, Cancer Nanotechnology (2025)

4. Dendrimer Functionalized Magnetic Nanoparticles As a Promising Platform for Localized Hyperthermia and Magnetic Resonance Imaging Diagnosis, Journal of Cellular Physiology (2019)

5. A Review Study of the Influences of Dendrimer Nanoparticles on Stored Platelet in Order to Treat Patients (2001-2020), Current Nanoscience (2022)

6. Atomistic Computer Simulations on Multi-Loaded Pamam Dendrimers: A Comparison of Amine- and Hydroxyl-Terminated Dendrimers, Journal of Computer-Aided Molecular Design (2017)

7. Classification of Stimuli-Responsive Polymers As Anticancer Drug Delivery Systems, Drug Delivery (2015)

8. A New Prospect in Magnetic Nanoparticle-Based Cancer Therapy: Taking Credit From Mathematical Tissue-Mimicking Phantom Brain Models, Nanomedicine: Nanotechnology# Biology# and Medicine (2017)

Experts (# of related papers)

View all Related Experts

Reza Saber (3)

Alimohammad Alizadeh (2)

Style	Citing Format
MLA	Salimi M, et al.. "Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles." Cancer Nanotechnology, vol. 9, no. 1, 2018, pp. -.
APA	Salimi M, Sarkar S, Saber R, Delavari H, Alizadeh AM, Mulder HT (2018). Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles. Cancer Nanotechnology, 9(1), -.
Chicago	Salimi M, Sarkar S, Saber R, Delavari H, Alizadeh AM, Mulder HT. "Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles." Cancer Nanotechnology 9, no. 1 (2018): -.
Harvard	Salimi M et al. (2018) 'Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles', Cancer Nanotechnology, 9(1), pp. -.
Vancouver	Salimi M, Sarkar S, Saber R, Delavari H, Alizadeh AM, Mulder HT. Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles. Cancer Nanotechnology. 2018;9(1):-.
BibTex	@article{ author = {Salimi M and Sarkar S and Saber R and Delavari H and Alizadeh AM and Mulder HT}, title = {Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles}, journal = {Cancer Nanotechnology}, volume = {9}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Salimi M AU - Sarkar S AU - Saber R AU - Delavari H AU - Alizadeh AM AU - Mulder HT TI - Magnetic Hyperthermia of Breast Cancer Cells and Mri Relaxometry With Dendrimer-Coated Iron-Oxide Nanoparticles JO - Cancer Nanotechnology VL - 9 IS - 1 SP - EP - PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract