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Investigation of Biological Activity and Hyperthermia Application of a Quaternary Magnetic Nanobiocomposite Based on Functionalized Carbon Nitride Nanosheets by Carboxymethyl Cellulose Hydrogel and Silk Fibroin Publisher



Eivazzadehkeihan R1 ; Gorab MG2 ; Aliabadi HAM3 ; Noruzi EB4 ; Kashtiaray A2 ; Bani MS5 ; Etminan A6 ; Mirzahoseini H7 ; Cohan RA1 ; Maleki A2 ; Mahdavi M8
Authors
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Authors Affiliations
  1. 1. Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  3. 3. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  4. 4. Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran
  5. 5. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  6. 6. School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  7. 7. Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  8. 8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellulose Published:2023


Abstract

Magnetic-responsive biopolymer composites have great potential for use in diverse biomedical applications. In this study, a new nanobiocomposite consisting of carbon nitride (CN), carboxymethyl cellulose (CMC) hydrogel, silk fibroin biopolymer, and magnetic iron oxide nanoparticles (Fe3O4 MNPs) was designed and fabricated. The synthesis procedure is based on the modification of the CN platform with CMC hydrogel and conjugation with SF biopolymer alongside in-situ magnetization with Fe3O4 MNPs. This hybrid magnetic nanobiocomposite was characterized by several analytical methods: FT-IR, EDX, SEM, XRD, TGA, and VSM. The in-vitro hemolysis assay confirmed the hemocompatibility of the prepared nanobiocomposite and its anticancer activity against breast cancer cell lines (BT549) was evaluated by MTT assay. Furthermore, the magnetic nanobiocomposite showed excellent potential for hyperthermia applications, with a maximum specific absorption rate of 7 W/g for 1 mg/mL of the sample under a magnetic field in different frequencies (100, 200, 300, and 400 MHz) and 5 to 20 min time intervals. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
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