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Novel Levofloxacin Derivatives As Potent Antibacterial Agents



Moshafi MH1 ; Bahador N1 ; Moghimi S2 ; Ejtemaei R2 ; Foroumadi A2, 3 ; Asadipour A3
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Sciences# Islamic Republic of Iran Published:2017

Abstract

In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synthesized compounds are strong antibacterial agents. All the synthesized compounds showed remarkable activities against Staphylococcus epidermidis and Staphylococcus aureus (MIC = 0.03-1 μg/mL and 0.06-1 μg/mL respectively). © 2017, National Research Center of Medical Sciences. All rights reserved.
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