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Nanotechnology for Angiogenesis: Opportunities and Challenges Publisher Pubmed



Kargozar S1 ; Baino F2 ; Hamzehlou S3, 4 ; Hamblin MR5, 6, 7 ; Mozafari M8
Authors
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Authors Affiliations
  1. 1. Tissue Engineering Research Group, Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 917794-8564, Iran
  2. 2. Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino Corso Duca degli Abruzzi 24, Torino, 10129, Italy
  3. 3. Molecular Pathology and Cytogenetics Laboratory, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Hematology/Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  6. 6. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  7. 7. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
  8. 8. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Chemical Society Reviews Published:2020


Abstract

Angiogenesis plays a critical role within the human body, from the early stages of life (i.e., embryonic development) to life-threatening diseases (e.g., cancer, heart attack, stroke, wound healing). Many pharmaceutical companies have expended huge efforts on both stimulation and inhibition of angiogenesis. During the last decade, the nanotechnology revolution has made a great impact in medicine, and regulatory approvals are starting to be achieved for nanomedicines to treat a wide range of diseases. Angiogenesis therapies involve the inhibition of angiogenesis in oncology and ophthalmology, and stimulation of angiogenesis in wound healing and tissue engineering. This review aims to summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail. Theranostic and imaging approaches can be facilitated by nanoparticles. Many preparations have been reported to have a bimodal effect where they stimulate angiogenesis at low dose and inhibit it at higher doses. This journal is © The Royal Society of Chemistry.
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