Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential

Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential Publisher Pubmed

Huldani H¹ ; Rashid AI² ; Turaev KN^{3, 4} ; Opulencia MJC⁵ ; Abdelbasset WK^{6, 7} ; Bokov DO^{8, 9} ; Mustafa YF¹⁰ ; Algazally ME¹¹ ; Hammid AT¹² ; Kadhim MM^{13, 14, 15} ; Ahmadi SH¹⁶

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1. Department of Physiology, Faculty of Medicine, Lambung Mangkurat University, South Kalimantan, Banjarmasin, Indonesia
2. Department of Pharmacology, Collage of Medicine, University of Babylon, Hilla, Iraq
3. Department of Clinical Pharmacology, Samarkand State Medical Institute, Samarkand, Uzbekistan
4. Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan
5. College of Business Administration, Ajman University, Ajman, United Arab Emirates
6. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia
7. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt
8. Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., Bldg. 2, Moscow, 119991, Russian Federation
9. Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky Pr, Moscow, 109240, Russian Federation
10. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
11. College of Medicine, University of Al-Ameed, Karbala, Iraq
12. Computer Engineering Techniques Department, Faculty of Information Technology, Imam Jaâ€™afar Al-Sadiq University, Baghdad, Iraq
13. Department of Dentistry, Kut University College, Wasit, Kut, 52001, Iraq
14. College of Technical Engineering, The Islamic University, Najaf, Iraq
15. Department of Pharmacy, Osol Aldeen University College, Baghdad, Iraq
16. Research Center for Cell and Molecular Sciences, School of Medicine, Tehran University of Medical Sciences, PO Box 1417613151, Tehran, Iran

Source: Cell Communication and Signaling Published:2022

Abstract

Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed that ConA can bind to several receptors on cancerous and normal cells and modulate the related signaling cascades. The most studied host receptor for ConA is MT1-MMP, responsible for most of the lectin's modulations, ranging from activating immune cells to killing tumor cells. In this study, in addition to studying the effect of ConA on signaling and immune cell function, we will focus on the most up-to-date advancements that unraveled the molecular mechanisms by which ConA can induce autophagy and apoptosis in various cancer cell types, where it has been found that P73 and JAK/STAT3 are the leading players. Moreover, we further discuss the main signaling molecules causing liver injury as the most significant side effect of the lectin injection. Altogether, these findings may shed light on the complex signaling pathways controlling the diverse responses created via ConA treatment, thereby modulating these complex networks to create more potent lectin-based cancer therapy. [MediaObject not available: see fulltext.] © 2022, The Author(s).

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Style	Citing Format
MLA	Huldani H, et al.. "Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential." Cell Communication and Signaling, vol. 20, no. 1, 2022, pp. -.
APA	Huldani H, Rashid AI, Turaev KN, Opulencia MJC, Abdelbasset WK, Bokov DO, Mustafa YF, Algazally ME, Hammid AT, Kadhim MM, Ahmadi SH (2022). Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential. Cell Communication and Signaling, 20(1), -.
Chicago	Huldani H, Rashid AI, Turaev KN, Opulencia MJC, Abdelbasset WK, Bokov DO, Mustafa YF, et al.. "Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential." Cell Communication and Signaling 20, no. 1 (2022): -.
Harvard	Huldani H et al. (2022) 'Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential', Cell Communication and Signaling, 20(1), pp. -.
Vancouver	Huldani H, Rashid AI, Turaev KN, Opulencia MJC, Abdelbasset WK, Bokov DO, et al.. Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential. Cell Communication and Signaling. 2022;20(1):-.
BibTex	@article{ author = {Huldani H and Rashid AI and Turaev KN and Opulencia MJC and Abdelbasset WK and Bokov DO and Mustafa YF and Algazally ME and Hammid AT and Kadhim MM and Ahmadi SH}, title = {Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential}, journal = {Cell Communication and Signaling}, volume = {20}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Huldani H AU - Rashid AI AU - Turaev KN AU - Opulencia MJC AU - Abdelbasset WK AU - Bokov DO AU - Mustafa YF AU - Algazally ME AU - Hammid AT AU - Kadhim MM AU - Ahmadi SH TI - Concanavalin a As a Promising Lectin-Based Anti-Cancer Agent: The Molecular Mechanisms and Therapeutic Potential JO - Cell Communication and Signaling VL - 20 IS - 1 SP - EP - PY - 2022 ER -

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