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Innovating Chitosan-Based Bioinks for Dermal Wound Healing: Current Progress and Future Prospects Publisher Pubmed



Ghobadi F1, 2 ; Kalantarzadeh R2, 3 ; Ashrafnia Menarbazari A1, 2 ; Salehi G2, 3 ; Fatahi Y4, 5 ; Simorgh S2, 6 ; Orive G7, 8, 9, 10, 11 ; Dolatshahipirouz A12 ; Gholipourmalekabadi M2, 6, 13, 14
Authors
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Authors Affiliations
  1. 1. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Biomaterials Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Karaj, Iran
  4. 4. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, 01006, Spain
  8. 8. Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, 01009, Spain
  9. 9. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, Av Monforte de Lemos 3-5, Madrid, 28029, Spain
  10. 10. University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV/EHU-Fundacion Eduardo Anitua), Vitoria-Gasteiz, 01007, Spain
  11. 11. Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, 169856, Singapore
  12. 12. Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark
  13. 13. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  14. 14. NanoBiotechnology & Regenerative Medicine Innovation Group, Noavarn Salamat ZHINO (PHC), Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2025


Abstract

The field of three-dimensional (3D) bio/printing, known as additive manufacturing (AM), heavily relies on bioinks possessing suitable mechanical properties and compatibility with living cells. Among the array of potential hydrogel precursor materials, chitosan (CS) has garnered significant attention due to its remarkable physicochemical and biological attributes. These attributes include biodegradability, nontoxicity, antimicrobial properties, wound healing promotion, and immune system activation, making CS a highly appealing hydrogel-based bioink candidate. This review explores the transformative potential of CS-based bioink for enhancing dermal wound healing therapies. We highlight CS's unique qualities that make it an optimal choice for bioink development. Advancements in 3D bio/printing technology for tissue engineering (TE) are discussed, followed by an examination of strategies for CS-based bioink formulation and their impacts on wound healing. To address the progress in translating advanced wound healing from lab to clinic, we highlight the current and ongoing research in CS-based bioink for 3D bio/printing in skin wound healing applications. Finally, we explore current evidence, commercialization prospects, emerging innovations like 4D printing, and the challenges and future directions in this promising field. © 2025 Elsevier B.V.
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