Innovating Chitosan-Based Bioinks for Dermal Wound Healing: Current Progress and Future Prospects Publisher Pubmed



Ghobadi F^{1, 2} ; Kalantarzadeh R^{2, 3} ; Ashrafnia Menarbazari A^{1, 2} ; Salehi G^{2, 3} ; Fatahi Y^{4, 5} ; Simorgh S^{2, 6} ; Orive G^{7, 8, 9, 10, 11} ; Dolatshahipirouz A¹² ; Gholipourmalekabadi M^{2, 6, 13, 14}
Source: International Journal of Biological Macromolecules Published:2025

Abstract

The field of three-dimensional (3D) bio/printing, known as additive manufacturing (AM), heavily relies on bioinks possessing suitable mechanical properties and compatibility with living cells. Among the array of potential hydrogel precursor materials, chitosan (CS) has garnered significant attention due to its remarkable physicochemical and biological attributes. These attributes include biodegradability, nontoxicity, antimicrobial properties, wound healing promotion, and immune system activation, making CS a highly appealing hydrogel-based bioink candidate. This review explores the transformative potential of CS-based bioink for enhancing dermal wound healing therapies. We highlight CS's unique qualities that make it an optimal choice for bioink development. Advancements in 3D bio/printing technology for tissue engineering (TE) are discussed, followed by an examination of strategies for CS-based bioink formulation and their impacts on wound healing. To address the progress in translating advanced wound healing from lab to clinic, we highlight the current and ongoing research in CS-based bioink for 3D bio/printing in skin wound healing applications. Finally, we explore current evidence, commercialization prospects, emerging innovations like 4D printing, and the challenges and future directions in this promising field. © 2025 Elsevier B.V.