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A Systematic Review and Meta-Analysis on the Prevalence of Kras Gene Mutation in Samples of Colorectal Cancer Publisher



Sadough A1 ; Afshari M2 ; Rostami F3 ; Barzegari S4 ; Janbabaee G5 ; Tabrizi R6 ; Akbari M6 ; Alizadehnavaei R7 ; Hedayatizadehomran A7 ; Moosazadeh M8
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Authors Affiliations
  1. 1. Faculty of Iranian Medicine, Traditional Medicine and History of Medical Science Research Center, Babol University of Medical Science, Babol, Iran
  2. 2. Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
  3. 3. Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Gastrointestinal Cancer Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Health Sciences Research Center, Add, iction Institute, Mazandaran University of Medical Sciences, Sari, Iran

Source: World Cancer Research Journal Published:2020


Abstract

Objective: Mutation in KRAS gene is one of the most common genetic changes among patients with colorectal cancer (CRC), which is observed in 30-45% of cases. This study aims to estimate the prevalence of this mutation among patients with primary or metastatic CRC. Patients and Methods: Eligible studies were identified during a comprehensive electronic search, applying inclusion/exclusion criteria and quality assessment. Stata version 11 software was used for data analysis. The heterogeneity between the results of the primary studies was assessed using Cochrane and I-square indices. Random effect model was applied for combining the primary estimates. Point and pooled estimates (with 95% confidence intervals) were presented by forest plots. Investigating the factors associated with heterogeneity was carried out using meta-regression models. The publication bias was traced by Egger test. Results: Combining the results of 164 eligible studies, the total prevalence of KRAS gene mutation among primary tumor samples was estimated as of 33.14% (95% confidence interval: 30.0836.20). The corresponding figure for metastatic cancer was estimated as of 36.20 % (95% confidence interval: 33.96-38.44). Prevalence of this mutation among patients with primary CRC in EMRO, EURO, PAHO, SEARO and WAPRO was 30.23%, 35.12%, 31.83%, 33.17% and 32.64%, respectively. Corresponding rates for mutation among metastatic cases were 42.20%, 38.46%, 36.06%, 42.80%, 33.05%, respectively. In addition, the total prevalence of KRAS gene mutation in codons 12 and 13 was estimated as 76.69% and 28.49%, respectively. Conclusions: More than one-third of patients with CRC carried KRAS gene mutation particularly in the metastatic tumors. The rate of mutation was the same in different WHO regions. © 2020, Verduci International. All rights reserved.
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