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The Effect of Atorvastatin on the Blood-Brain Barrier Biomarkers in Acute Intracerebral Hemorrhage, a Pilot Clinical Trial Publisher



Simani L1 ; Ramezani M1, 5 ; Ahmadi N2 ; Abazari F3 ; Raminfard S4 ; Shojaei M2 ; Zoghi A2 ; Karimialavijeh E6 ; Hossein Aghamiri S7 ; Pakdaman H5
Authors
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Authors Affiliations
  1. 1. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Department of Neurology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Advanced Medical Technologies and Equipment Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Brain Mapping Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Sina Hospital, Tehran University of Medical Sciences, Iran
  7. 7. School of Medicine, Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Brain Hemorrhages Published:2023


Abstract

Objective: Prior studies have shown statins provide neuroprotection by targeting secondary brain injury pathways and regulating cytokine production. We aimed to evaluate the association between statin administration and molecular outcomes in acute Intracranial hemorrhages (ICHs). Methods: Adult patients with acute spontaneous ICH were recruited and randomly allocated into two groups: group A received atorvastatin (40 mg/day) orally in addition to routine antihypertensive medications, while group B only received routine antihypertensives. Serum levels of matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor (VEGF), as primary outcomes, were measured at baseline, and after 45 days. Results: Thirty-nine ICH patients (group A: 20; group B: 19) were analyzed. A notable elevation in VEGF and a reduction in MMP-9 levels were detected in group A compared to those in group B (P-value = 0.024 and 0.008, respectively). Conclusion: Our data suggest that atorvastatin in the acute phase of ICH could improve the serum levels of neuroprotective molecular biomarkers. © 2022 International Hemorrhagic Stroke Association. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
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