A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines

A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines Publisher

Salek Soltani S¹ ; F Farnia SM¹ ; Foroumadi A^{2, 3}

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2020

Abstract

Two efficient synthetic routes to preparation of 2,3-diarylimidazo[1,2-a]pyrazines and 2,3-diarylimidazo[1,2-b]pyridazines are described. The procedures involve a Suzuki cross-coupling reaction and a palladium-catalyzed direct arylation at position 3 and finally a comparative study is achieved. The antibacterial activities of the synthesized compounds in vitro were measured and the results showed that most products presented moderate to good antibacterial activities. Compounds 3a, 3c, 3j, 3k, 3l, and 3n revealed obvious potency against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli with minimum inhibitory concentration values of 32 μg/mL, which were better compared with the others. © 2020 Wiley Periodicals, Inc.

Style	Citing Format
MLA	Salek Soltani S, F Farnia SM, Foroumadi A. "A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines." Journal of Heterocyclic Chemistry, vol. 57, no. 4, 2020, pp. 1770-1780.
APA	Salek Soltani S, F Farnia SM, Foroumadi A (2020). A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines. Journal of Heterocyclic Chemistry, 57(4), 1770-1780.
Chicago	Salek Soltani S, F Farnia SM, Foroumadi A. "A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines." Journal of Heterocyclic Chemistry 57, no. 4 (2020): 1770-1780.
Harvard	Salek Soltani S, F Farnia SM, Foroumadi A (2020) 'A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines', Journal of Heterocyclic Chemistry, 57(4), pp. 1770-1780.
Vancouver	Salek Soltani S, F Farnia SM, Foroumadi A. A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines. Journal of Heterocyclic Chemistry. 2020;57(4):1770-1780.
BibTex	@article{ author = {Salek Soltani S and F Farnia SM and Foroumadi A}, title = {A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines}, journal = {Journal of Heterocyclic Chemistry}, volume = {57}, number = {4}, pages = {1770-1780}, year = {2020} }
RIS	TY - JOUR AU - Salek Soltani S AU - F Farnia SM AU - Foroumadi A TI - A Comparison Between Suzuki Cross-Coupling Reaction and Direct Arylation in the Synthesis of New Antibacterial Imidazo-Pyrazines/Pyridazines JO - Journal of Heterocyclic Chemistry VL - 57 IS - 4 SP - 1770 EP - 1780 PY - 2020 ER -

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