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The Chimera of S1 and N Proteins of Sars-Cov-2: Can It Be a Potential Vaccine Candidate for Covid-19? Publisher Pubmed



Kumar A1 ; Ladha A2 ; Choudhury A3 ; Ikbal AMA4 ; Bhattacharjee B5 ; Das T6 ; Gupta G2, 7 ; Sharma C2 ; Sarbajna A8 ; Mandal SC9 ; Choudhury MD1 ; Ali N10 ; Slama P11 ; Rezaei N12, 13, 14 Show All Authors
Authors
  1. Kumar A1
  2. Ladha A2
  3. Choudhury A3
  4. Ikbal AMA4
  5. Bhattacharjee B5
  6. Das T6
  7. Gupta G2, 7
  8. Sharma C2
  9. Sarbajna A8
  10. Mandal SC9
  11. Choudhury MD1
  12. Ali N10
  13. Slama P11
  14. Rezaei N12, 13, 14
  15. Palit P15
  16. Tiwari ON16
Show Affiliations
Authors Affiliations
  1. 1. Department of Life Sciences and Bioinformatics, Assam University, Silchar, India
  2. 2. Area of Biotechnology and Bioinformatics, NIIT University, Neemrana, India
  3. 3. Department of Pharmaceutical Sciences, Allama TR College of Pharmacy, Hospital Rd, Srigouri, India
  4. 4. Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura (W), India
  5. 5. Department of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh, India
  6. 6. Department of Business Administration, Assam University, Silchar, India
  7. 7. Department of Immunology, University of Manitoba, Winnipeg, MB, Canada
  8. 8. Department of Zoology, Surendranath College, Kolkata, India
  9. 9. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
  10. 10. Division of Immunology, Department of Infectious Diseases, INDIAN INSTITUTE OF CHEMICAL BIOLOGY, Kolkata, India
  11. 11. Laboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology, and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, Brno, Czech Republic
  12. 12. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  14. 14. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden
  15. 15. Department of Pharmaceutical Sciences Drug Discovery research Laboratory, Assam University, Silchar, India
  16. 16. Centre for Conservation and Utilisation of Blue Green Algae (CCUBGA), Division of Microbiology, ICAR-Indian Agricultural Research Institute, IARI, New Delhi, India

Source: Expert Review of Vaccines Published:2022


Abstract

Introduction: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the biggest global health issues. Spike protein (S) and nucleoprotein (N), the major immunogenic components of SARS-CoV-2, have been shown to be involved in the attachment and replication of the virus inside the host cell. Areas covered: Several investigations have shown that the SARS-CoV-2 nucleoprotein can elicit a cell-mediated immune response capable of regulating viral replication and lowering viral burden. However, the development of an effective vaccine that can stop the transmission of SARS-CoV-2 remains a matter of concern. Literature was retrieved using the keywords COVID-19 vaccine, role of nucleoprotein as vaccine candidate, spike protein, nucleoprotein immune responses against SARS-CoV-2, and chimera vaccine in PubMed, Google Scholar, and Google. Expert opinion: We have focussed on the use of chimera protein, consisting of N and S-1 protein components of SARS-CoV-2, as a potential vaccine candidate. This may act as a polyvalent mixed recombinant protein vaccine to elicit a strong T and B cell immune response, which will be capable of neutralizing the wild and mutated variants of SARS-CoV-2, and also restricting its attachment, replication, and budding in the host cell. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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