Fibrosis Score 4 Index Has an Independent Relationship With Coronary Artery Diseases in Patients With Metabolic-Associated Fatty Liver Disease Publisher



Namakchian M¹ ; Rabizadeh S¹ ; Seifouri S¹ ; Asadigandomani H¹ ; Bafrani MA¹ ; Seifouri K¹ ; Avanaki FA² ; Rajab A¹ ; Nakhjavani M¹ ; Esteghamati A¹ Show Affiliations
Source: Diabetology and Metabolic Syndrome Published:2023

Abstract

Background: Metabolic-associated fatty liver disease (MAFLD), one of the most common liver diseases, is detected in patients with concomitant hepatic steatosis and Type 2 Diabetes (T2D). We looked into the relationship between Fibrosis-4 (FIB-4) index and coronary artery diseases (CAD) in patients with MAFLD, to further look into the efficiency of FIB-4 in screening for CAD among patients with MAFLD. Method: In this study, we included 1664 patients with MAFLD (T2D, who also had hepatic steatosis) during 2012–2022 and divided them into 2 groups; CAD and non-CAD. Demographic, Anthropometric indices, liver function tests, lipid profile and FIB-4 index of all patients were evaluated and compared. Result: Among the 1644 patients (all have MAFLD), 364(21.4%) had CAD. Patients with MAFLD and CAD were more probable to be hypertensive, have longer duration of diabetes and be older (with p-values < 0.001). After adjustment for confounding factors, in a multivariable logistic regression model, FIB4 showed a significant independent relationship with concomitant MAFLD and CAD. Upper Tertile FIB-4 had an odds ratio of 3.28 (P-value = 0.002) to predict CAD. Furthermore, in Receiver Operating Characteristic (ROC) Curve analysis with the maximum Youden Index, a FIB-4 cut-off of 0.85 (AUC = 0.656, 95% CI 0.618–0.693, P < 0.001) noted to predict CAD in patients with MAFLD. Conclusion: This study showed that the FIB-4 score independently correlates with CAD in patients with MAFLD. © 2023, The Author(s).