Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line

Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line Publisher Pubmed

Jamali Z¹ ; Hejazi SM^{2, 3} ; Ebrahimi SM³ ; Moradisardareh H¹ ; Paknejad M¹

Show Affiliations

1. Department of Medical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Bio Optical Imaging Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran

Source: Photodiagnosis and Photodynamic Therapy Published:2018

Abstract

Photodynamic therapy (PDT) has received high attention in cancer treatment due to its minimal side effects, specific cancer-targeting, non-invasion and low cost. It utilizes a specific group of anti-cancer drugs called photosensitizers (PS), which can be only activated under a certain wavelength light illumination and kills cancer cells. To screen the potential of PS and setup of PDT treatment protocol, it is essential to assess the PDT efficacy in vitro. In this study, a light-emitting diode- (LED-) based illumination system at two wavelengths (red & blue) with homogeneous and stable irradiation, and constant temperature conditions in 96-well plates was provided. The photodynamic effect of curcumin (CUR) and methyl ester of 5-aminolevulinic acid (MAL) using LED light on human glioma cell line was investigated. The obtained results indicate that this homemade LED-based illumination system is a favorable light source for in vitro PDT in 96-well plates. The PDT using CUR and MAL was efficient at final concentrations of 25 μM and 2 mM, and light doses of 60 J/cm2 and 40 J/cm2 respectively. The blue PDT efficiency was dependent on the light and PS doses. MAL-PDT and CUR-PDT using blue LED significantly decreased cell viability in the treatment groups compared with control groups. Furthermore, MAL-PDT using blue LEDs was more effective in comparison with conventional red LEDs on the human glioma cell line. © 2017 Elsevier B.V.

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Style	Citing Format
MLA	Jamali Z, et al.. "Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line." Photodiagnosis and Photodynamic Therapy, vol. 21, no. , 2018, pp. 50-54.
APA	Jamali Z, Hejazi SM, Ebrahimi SM, Moradisardareh H, Paknejad M (2018). Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line. Photodiagnosis and Photodynamic Therapy, 21(), 50-54.
Chicago	Jamali Z, Hejazi SM, Ebrahimi SM, Moradisardareh H, Paknejad M. "Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line." Photodiagnosis and Photodynamic Therapy 21, no. (2018): 50-54.
Harvard	Jamali Z et al. (2018) 'Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line', Photodiagnosis and Photodynamic Therapy, 21(), pp. 50-54.
Vancouver	Jamali Z, Hejazi SM, Ebrahimi SM, Moradisardareh H, Paknejad M. Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line. Photodiagnosis and Photodynamic Therapy. 2018;21():50-54.
BibTex	@article{ author = {Jamali Z and Hejazi SM and Ebrahimi SM and Moradisardareh H and Paknejad M}, title = {Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line}, journal = {Photodiagnosis and Photodynamic Therapy}, volume = {21}, number = {}, pages = {50-54}, year = {2018} }
RIS	TY - JOUR AU - Jamali Z AU - Hejazi SM AU - Ebrahimi SM AU - Moradisardareh H AU - Paknejad M TI - Effects of Led-Based Photodynamic Therapy Using Red and Blue Lights, With Natural Hydrophobic Photosensitizers on Human Glioma Cell Line JO - Photodiagnosis and Photodynamic Therapy VL - 21 IS - SP - 50 EP - 54 PY - 2018 ER -

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