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The Association Between Nonalcoholic Fatty Liver Disease and Corrected Qt Interval Prolongation Among Generally Healthy Iranian Population: Fasa Cohort Study (Facs) Publisher Pubmed



Naderi A1 ; Farjam M2 ; Mojarrad Sani M3 ; Abdollahi A4 ; Alkamel A2 ; Keshavarzian O4 ; Tabrizi R2, 5
Authors
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Authors Affiliations
  1. 1. Department of Medicine, USERN Office, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Science, Fasa, Iran
  3. 3. Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran

Source: Clinical Cardiology Published:2023


Abstract

Background: There are limited studies about the association between nonalcoholic fatty liver disease (NAFLD) and corrected QT interval (QTc) prolongation worldwide. Hypothesis: Therefore, we designed the current study to determine this association in a large cohort of a generally healthy population. Methods: We analyzed the data of 4603 individuals aged 35–70 who participated in the Fasa Cohort Study (FACS). Based on 12-lead electrocardiograms, QT intervals were calculated and corrected by Bazzet's formula. A QTc interval of more than 430 ms in men and 450 ms in women was considered prolonged. The Fatty Liver Index was used to identify the participants with NAFLD. Results: Of all participants, 1550 (33.6%) met the NAFLD criteria. In subjects of both genders with NAFLD, the mean values of the QTc interval were considerably higher than in those without NAFLD (p <.001). After adjusting for a wide range of confounders, including age, gender, smoking status, physical activity, total cholesterol, high-density lipoprotein-cholesterol levels, diabetes, and hypertension status, in linear regression analysis, the standardized β coefficient of QTc interval among participants with NAFLD was 2.56 ms (95% confidence interval [CI]: 0.49–4.64). After controlling the same confounders, the odds ratio of NAFLD for a prolonged QTc interval in men was 1.47 (95% CI: 1.18–1.84; p <.001) and in women was 1.39 (95% CI: 1.15–1.68; p <.001) using logistic regression analysis. Conclusions: NAFLD was a risk factor for QTc interval prolongation. Awareness about the risk of NAFLD in increasing the potential cardiac arrhythmias should be raised to lower cardiac mortality. © 2023 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.
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