The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis

The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis Publisher Pubmed

Tabatabaei SA¹ ; Soleimani M¹ ; Tabatabaei SM¹ ; Beheshtnejad AH¹ ; Valipour N¹ ; Mahmoudi S^{2, 3}

Show Affiliations

1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Studentsâ€™ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Ophthalmology Published:2020

Abstract

Purpose: To evaluate the usefulness of serial in vivo confocal microscopy (IVCM) examinations to measure hyphal density for monitoring the treatment success among patients with fungal keratitis, and to compare the hyphal diameter as well as branching angle as a way of differentiation between Aspergillus and Fusarium species observed in IVCM. Study design: Prospective nonrandomized study. Patients and methods: The study was conducted from February 2015 to September 2016. Hyphal diameter, density and branching angle measurements were performed using IVCM at admission and on a weekly basis for at least 2 weeks after the start of treatment. Results: During the period of study, 65 patients with culture-confirmed fungal keratitis were recruited. Of them, 40 were culture-positive for Fusarium spp. and 25 patients for Aspergillus spp. Before the start of treatment, the mean branching angle did not differ between the two species and the mean hyphal diameter was statistically higher for Aspergillus spp. (p = 0.029). Two weeks after the start of treatment, the mean hyphal diameter was statistically lower (p < 0.001) in the treatment failure group. Also the hyphal density significantly decreased with successful treatment (p < 0.05). Conclusion: Decreasing hyphal density in serial IVCMs might be used as an indicator to predict the successful response of fungal ulcers to treatment. Branching angle is not different between Aspergillus and Fusarium keratitis. The mean hyphal diameter is significantly lower in the treatment failure group. © 2019, Springer Nature B.V.

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Experts (# of related papers)

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Mohammad Soleimani (5)

Ali Tabatabaei (2)

Style	Citing Format
MLA	Tabatabaei SA, et al.. "The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis." International Ophthalmology, vol. 40, no. 2, 2020, pp. 483-491.
APA	Tabatabaei SA, Soleimani M, Tabatabaei SM, Beheshtnejad AH, Valipour N, Mahmoudi S (2020). The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis. International Ophthalmology, 40(2), 483-491.
Chicago	Tabatabaei SA, Soleimani M, Tabatabaei SM, Beheshtnejad AH, Valipour N, Mahmoudi S. "The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis." International Ophthalmology 40, no. 2 (2020): 483-491.
Harvard	Tabatabaei SA et al. (2020) 'The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis', International Ophthalmology, 40(2), pp. 483-491.
Vancouver	Tabatabaei SA, Soleimani M, Tabatabaei SM, Beheshtnejad AH, Valipour N, Mahmoudi S. The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis. International Ophthalmology. 2020;40(2):483-491.
BibTex	@article{ author = {Tabatabaei SA and Soleimani M and Tabatabaei SM and Beheshtnejad AH and Valipour N and Mahmoudi S}, title = {The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis}, journal = {International Ophthalmology}, volume = {40}, number = {2}, pages = {483-491}, year = {2020} }
RIS	TY - JOUR AU - Tabatabaei SA AU - Soleimani M AU - Tabatabaei SM AU - Beheshtnejad AH AU - Valipour N AU - Mahmoudi S TI - The Use of in Vivo Confocal Microscopy to Track Treatment Success in Fungal Keratitis and to Differentiate Between Fusarium and Aspergillus Keratitis JO - International Ophthalmology VL - 40 IS - 2 SP - 483 EP - 491 PY - 2020 ER -

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