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Macromolecular Biomarkers of Chronic Obstructive Pulmonary Disease in Exhaled Breath Condensate Publisher Pubmed



Kazeminasab S1, 2 ; Emamalizadeh B3 ; Jouyban A1, 4 ; Shoja MM5 ; Khoubnasabjafari M6, 7
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran
  2. 2. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 51666-14756, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, 14117-13135, Iran
  5. 5. Department of Surgery, University of Texas Medical Branch, Galveston, TX, United States
  6. 6. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran
  7. 7. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, 51666-14756, Iran

Source: Biomarkers in Medicine Published:2020


Abstract

Biomarkers provide important diagnostic and prognostic information on heterogeneous diseases such as chronic obstructive pulmonary disease (COPD). However, finding a suitable specimen for clinical analysis of biomarkers for COPD is challenging. Exhaled breath condensate (EBC) sampling is noninvasive, rapid, cost-effective and easily repeatable. EBC sampling has also provided recent progress in the identification of biological macromolecules, such as lipids, proteins and DNA in EBC samples, which has increased its utility for clinical scientists. In this article, we review applications involving EBC sampling for the analysis of COPD biomarkers and discuss its future potential. © 2020 Future Medicine Ltd.
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