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Regulatory T Cells in the Blood of Patients With Chronic Obstructive Pulmonary Disease (Copd): A Systematic Review and Meta-Analysis Publisher Pubmed



Jalalvand M1 ; Tahermohammadi H2 ; Madreseh E3, 4 ; Varahram M5 ; Sharifi H6 ; Akhtari M6 ; Jamaati H2
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Respiratory Medicine Published:2025


Abstract

Background: Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of mortality and morbidity worldwide. Due to the lack of effective treatments for COPD, targeting regulatory T-cells (Treg) has recently attracted considerable attention. Therefore, we conducted a systematic review and meta-analysis to review all of the existing data about the percentage of Treg cells in peripheral blood samples of COPD patients to discover the potential role of these cells in finding new treatments for these patients. Methods: We explored SCOPUS, PubMed, and Web of Science databases using search terms like “Chronic obstructive pulmonary disease”, “Emphysema”, “suppressive lymphocyte”, and “Regulatory T Cell”. Data regarding the number of COPD patients and healthy subjects, Treg cell identification, definition of Treg cell markers, and the percentage of Tregs in COPD patients and controls, in addition to smoking, and clinical status of COPD patients were extracted. Results: The overall assessment showed no significant difference in the frequency of Treg cells between COPD patients and healthy subjects. No remarkable difference in Treg frequencies was observed in subgroup analysis based on the markers used to define Tregs, the clinical state of COPD patients, and the patient's smoking history. Based on our results, smoking reduces the level of Treg cells in the body. The frequency of CD4+CD25+FoxP3+ Tregs was considerably lower in the blood of smokers than in non-smoking healthy individuals. Conclusion: The overall result of this meta-analysis points out the importance of smoking in the prevalence of peripheral blood Treg cells. © 2025 Elsevier Ltd
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