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Update on the Efficacy of Statins in Primary and Secondary Prevention of Atrial Fibrillation; [Atualizacoes Sobre a Eficacia Das Estatinas Na Prevencao Primaria E Secundaria Da Fibrilacao Auricular] Publisher Pubmed



Oraii A1 ; Vasheghanifarahani A2, 3 ; Oraii S4 ; Roayaei P3 ; Balali P1 ; Masoudkabir F2, 3
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Authors Affiliations
  1. 1. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Cardiac Electrophysiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Interventional electrophysiologist, Tehran Arrhythmia Clinic, Tehran, Iran

Source: Revista Portuguesa de Cardiologia Published:2021


Abstract

Atrial fibrillation is the most common arrhythmia in adults and its prevalence is growing rapidly. It has been shown that AF is associated with increased risk of heart failure, ischemic and hemorrhagic stroke, and mortality. Hence, there is growing interest among researchers in seeking preventive and therapeutic interventions regarding AF. In recent decades, it has been suggested that statins may decrease the incidence of AF and may also decrease its recurrence after cardioversion and catheter ablation. These effects are thought to be mediated by different mechanisms such as modulating inflammation, altering the properties of transmembrane ion channels, interfering with activation of matrix metalloproteinases, and acting on endothelial function. In this article, we review and update current knowledge about the role of statins in primary and secondary prevention of AF in general and specific populations. © 2021
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