Regenerative Medicine and Endocrinology: Advanced Cell Therapies for Diabetes Publisher



Ghezelayagh Z ; Tahamtani Y ; Valizadeh M ; Aghayan HR
Source: Interdisciplinary Advances in Endocrinology Published:2025

Abstract

Diabetes mellitus (DM) and its complications pose significant health challenges worldwide. Many therapeutic approaches have been suggested for DM, but none are considered optimal solutions. Regenerative medicine (RM) is a promising branch of medical science that offers new therapeutic modalities for some chronic incurable diseases including DM. RM can be classified into four main categories: cell therapy, tissue engineering, gene therapy, and cell-free therapeutics. Pancreatic islet transplantation is a cell-based therapy for diabetes that predates the introduction of the RM concept. Newer strategies, such as mesenchymal stem cell transplantation, transplantation of islet progenitors or insulin-producing cells, and the application of tissue-engineered biological dressings, are examples of promising regenerative therapies for DM and its complications. This chapter presents some new advancements in the field of diabetes regenerative therapies focusing on cell-based approaches and organoid technologies. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.