Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk

Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk Publisher

Saki N¹ ; Sarhangi N² ; Afshari M³ ; Bandarian F⁴ ; Aghaei Meybodi HR^{2, 5} ; Hasanzad M¹

Show Affiliations

1. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
4. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2020

Abstract

Background: Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. The genetic variants of Melatonin Receptor 1B (MTNR1B) are reported to be associated with type 2 diabetes mellitus(T2DM) susceptibility. Purpose: To investigate the association of MTNR1B common variant, rs10830963 (C/G), with the risk of T2DM in a group of Iranian population. Methods: 187 T2DM (case) and 100 normal individuals (control) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: There were significant difference in frequency of genotypes and alleles of rs10830963 in patient and control groups (P = 0.003, P = 0.0008, respectively). The GG, CG genotypes and also G allele increased risk of T2DM disease (OR: 2.63, OR: 1.87, and OR: 1.90 respectively). Conclusion: Our finding could suggest that rs10830963 variant in the MTNR1B gene is associated with the development of T2DM in a group of Iranian population. © 2020

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Experts (# of related papers)

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Hamidreza Aghaei Meybodi (4)

Reza Malekzadeh (1)

Style	Citing Format
MLA	Saki N, et al.. "Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk." Gene Reports, vol. 20, no. , 2020, pp. -.
APA	Saki N, Sarhangi N, Afshari M, Bandarian F, Aghaei Meybodi HR, Hasanzad M (2020). Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk. Gene Reports, 20(), -.
Chicago	Saki N, Sarhangi N, Afshari M, Bandarian F, Aghaei Meybodi HR, Hasanzad M. "Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk." Gene Reports 20, no. (2020): -.
Harvard	Saki N et al. (2020) 'Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk', Gene Reports, 20(), pp. -.
Vancouver	Saki N, Sarhangi N, Afshari M, Bandarian F, Aghaei Meybodi HR, Hasanzad M. Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk. Gene Reports. 2020;20():-.
BibTex	@article{ author = {Saki N and Sarhangi N and Afshari M and Bandarian F and Aghaei Meybodi HR and Hasanzad M}, title = {Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk}, journal = {Gene Reports}, volume = {20}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Saki N AU - Sarhangi N AU - Afshari M AU - Bandarian F AU - Aghaei Meybodi HR AU - Hasanzad M TI - Mtnr1b Common Genetic Variant Is Associated With Type 2 Diabetes Mellitus Risk JO - Gene Reports VL - 20 IS - SP - EP - PY - 2020 ER -

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