Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns

Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns Publisher Pubmed

Ebadati A^{1, 2, 3} ; Oshaghi M⁴ ; Saeedi S^{1, 2, 3} ; Parsa P⁵ ; Mahabadi VP^{1, 6} ; Karimi M^{3, 7, 8} ; Hajiebrahimdehi AJ^{1, 2, 3} ; Hamblin MR⁹ ; Karimi M^{3, 7, 8}

Show Affiliations

1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran
4. Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
5. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
6. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
7. Karen Diagnostic Laboratory, Varamin, Iran
8. Sepid Diagnostic Laboratory, Varamin, Iran
9. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
10. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
11. Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
12. Applied Biotechnology Research Centre, Tehran Medical Science, Islamic Azad University, Tehran, Iran

Source: Bioorganic Chemistry Published:2023

Abstract

Multi-drug resistant bacteria are a major problem in the treatment of infectious diseases, such as pneumonia, meningitis, or even coronavirus disease 2019 (COVID-19). Cationic nanopolymers are a new type of antimicrobial agent with high efficiency. We synthesized and characterized cationic polymer based on 1,4-diazabicyclo [2.2.2] octane (DABCO) and Bis (bromoacetyl)cystamine (BBAC), named poly (DABCO-BBAC) nanoparticles(NPs), and produced 150 nm diameter NPs. The antibacterial activity of poly (DABCO-BBAC) against eight multi drug resistant (MDR) Pseudomonas aeruginosa isolates from human burns, its possible synergistic effect with gentamicin, and the mechanism of action were examined. Poly(DABCO-BBAC) could effectively inhibit and kill bacterial strains at a very low concentration calculated by minimum inhibitory concentration (MIC) assay. Nevertheless, its synergism index with gentamicin showed an indifferent effect. Moreover, transmission electron microscopy and lipid peroxidation assays showed that poly (DABCO-BBAC) distorted and damaged the bacterial cell wall. These results suggest that the poly (DABCO-BBAC) could be an effective antibacterial agent for MDR clinical pathogens. © 2023

2. Beyond Antibiotics: Exploring Multifaceted Approaches to Combat Bacterial Resistance in the Modern Era: A Comprehensive Review, Frontiers in Cellular and Infection Microbiology (2025)

3. Potential Role of Metal Nanoparticles in Treatment of Peri-Implant Mucositis and Peri-Implantitis, BioMedical Engineering Online (2024)

Experts (# of related papers)

SeyedMohamad Hosseini Hooshiyar (1)

Style	Citing Format
MLA	Ebadati A, et al.. "Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns." Bioorganic Chemistry, vol. 140, no. , 2023, pp. -.
APA	Ebadati A, Oshaghi M, Saeedi S, Parsa P, Mahabadi VP, Karimi M, Hajiebrahimdehi AJ, Hamblin MR, Karimi M (2023). Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns. Bioorganic Chemistry, 140(), -.
Chicago	Ebadati A, Oshaghi M, Saeedi S, Parsa P, Mahabadi VP, Karimi M, Hajiebrahimdehi AJ, Hamblin MR, Karimi M. "Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns." Bioorganic Chemistry 140, no. (2023): -.
Harvard	Ebadati A et al. (2023) 'Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns', Bioorganic Chemistry, 140(), pp. -.
Vancouver	Ebadati A, Oshaghi M, Saeedi S, Parsa P, Mahabadi VP, Karimi M, et al.. Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns. Bioorganic Chemistry. 2023;140():-.
BibTex	@article{ author = {Ebadati A and Oshaghi M and Saeedi S and Parsa P and Mahabadi VP and Karimi M and Hajiebrahimdehi AJ and Hamblin MR and Karimi M}, title = {Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns}, journal = {Bioorganic Chemistry}, volume = {140}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Ebadati A AU - Oshaghi M AU - Saeedi S AU - Parsa P AU - Mahabadi VP AU - Karimi M AU - Hajiebrahimdehi AJ AU - Hamblin MR AU - Karimi M TI - Mechanism and Antibacterial Synergies of Poly(Dabco-Bbac) Nanoparticles Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolates From Human Burns JO - Bioorganic Chemistry VL - 140 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract