Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Possible Interaction of Hippocampal Nitric Oxide and Calcium/Calmodulin-Dependent Protein Kinase Ii on Reversal of Spatial Memory Impairment Induced by Morphine Publisher Pubmed



Farahmandfar M1, 2 ; Kadivar M3 ; Naghdi N4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran

Source: European Journal of Pharmacology Published:2015


Abstract

The opioid system plays an important role in learning and memory by modulation of different molecules in the brain. The aim of the present study was to investigate the role of hippocampal nitric oxide and calcium/calmodulin-dependent protein kinase II (CaMKII) on the morphine-induced modulation of spatial memory consolidation in male rats. Spatial memory was assessed in Morris water maze task by a single training session of eight trials followed by a probe trial and visible test 24 h later. Our data indicated that post-training administration of l-arginine, a nitric oxide precursor (6 and 9 μg/rat, intra-CA1) significantly decreased amnesia induced by morphine (10 mg/kg) in spatial memory consolidation. A reversal effect of l-arginine on morphine-induced amnesia prevented by KN-93 (N-[2-(N-(4-chlorocinnamyl)-N-methylaminomethyl) phenyl]-N-[2-hydroxyethyl] methoxybenzenesulfnamide), CaMKII inhibitor, (10 nmol/0.5 μl/site). In addition, post-training injection of l-NAME, (NG-nitro-l-arginine methyl ester), a nitric oxide synthase (NOS) inhibitor (10 and 15 μg/rat) or KN-93 (10 nmol/0.5 μl/site) with lower dose of morphine (2.5 mg/kg), which did not induce amnesia by itself, caused inhibition of memory consolidation. We also showed that co-administration of l-arginine (9 μg/rat) and morphine (10 mg/kg) significantly increased CaMKII activity in the rat hippocampus. On the other hand, administration of l-NAME (10 μg/rat) led to a decrease in the haippocampal activity of CaMKII in morphine-treated (2.5 mg/kg) animals. These results indicate that acute single exposure to morphine can modulate consolidation of spatial memory, which may be mediated by a hippocampal nitrergic system and CaMKII activity. © 2015 Published by Elsevier B.V.
Related Docs
View other Related Docs
1. Blockade of Dorsal Hippocampal Orexin-1 Receptors Impaired Morphine-Induced State-Dependent Learning, Neuropeptides (2016)
2. Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory, Iranian Journal of Psychiatry (2015)
3. The Dorsal Hippocampal Group Iii Metabotropic Glutamate Receptors Are Involved in Morphine Effect on Memory Formation in Male Mice, European Journal of Pharmacology (2018)
4. Repeated Pre-Exposure to Morphine Inhibited the Amnesic Effect of Ethanol on Spatial Memory: Involvement of Camkii and Bdnf, Alcohol (2024)
5. The Role of Calcium-Calmodulin-Dependent Protein Kinase Ii in Modulation of Spatial Memory in Morphine Sensitized Rats, Behavioural Brain Research (2019)
6. Effect of Pretreatment With Intracerebroventricular Injection of Minocycline on Morphine-Induced Memory Impairment in Passive Avoidance Test: Role of P-Creb and C-Fos Expression in the Dorsal Hippocampus and Basolateral Amygdala Regions, Clinical and Experimental Pharmacology and Physiology (2019)
7. Cross State-Dependent Memory Retrieval Between Morphine and Norharmane in the Mouse Dorsal Hippocampus, Brain Research Bulletin (2019)
8. Influence of Morphine on Medial Prefrontal Cortex Alpha2 Adrenergic System in Passive Avoidance Learning in Rats, Pharmacology Biochemistry and Behavior (2015)
Experts (# of related papers)
View all Related Experts
Maryam Farahmandfar (5)
Ahmad Reza Dehpour (4)
Other Related Docs
9. State-Dependent Memory and Its Modulation by Different Brain Areas and Neurotransmitters, EXCLI Journal (2020)
10. Role of Dorsal Hippocampal Orexin-1 Receptors in Memory Restoration Induced by Morphine Sensitization Phenomenon, Neuroscience (2016)
11. Μ-Opioid Receptor in the Ca1 Involves in Tramadol and Morphine Cross State-Dependent Memory, Neuroscience Letters (2019)
12. Synergistic Effect Between Quinpirole and L-Name As Well As Sulpiride and L-Arginine on the Modulation of Anxiety and Memory Processes in the 6-Ohda Mouse Model of Parkinson's Disease: An Isobologram Analysis, Neurobiology of Learning and Memory (2021)
13. Neurophysiologic Implications of Neuronal Nitric Oxide Synthase, Reviews in the Neurosciences (2020)
14. Function of Opioidergic and Dopaminergic Antagonists on Both Spatial and Object Novelty Detection Deficits Induced in Rodent Model of Hepatic Encephalopathy, Behavioural Brain Research (2016)
15. Activation of D1-Like Dopamine Receptors Is Involved in the Impairment of Spatial Memory in the Offspring of Morphine-Abstinent Rats, Neuroscience Research (2020)
16. Injection of Insulin Amyloid Fibrils in the Hippocampus of Male Wistar Rats: Report on Memory Impairment and Formation of Amyloid Plaques, Neurological Sciences (2015)
17. The Neuroprotective Effect of Neuroaid on Morphine-Induced Amnesia With Respect to the Expression of Tfam, Pgc-1Α, Δfosb and Cart Genes in the Hippocampus of Male Wistar Rats, Gene (2020)
18. Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring, Neuroscience (2021)
19. Effect of Nucleus Accumbens Shell 5-Ht4 Receptors on the Impairment of Acpa-Induced Emotional Memory Consolidation in Male Wistar Rats, Behavioural Pharmacology (2016)
20. Neuroprotective Effect of New Nanochelating-Based Nano Complex, Alzc3, Against Aβ (1–42)-Induced Toxicity in Rat: A Comparison With Memantine, Pharmaceutical Research (2020)
21. Synergistic Effect Between D-Ap5 and Muscimol in the Nucleus Accumbens Shell on Memory Consolidation Deficit in Adult Male Wistar Rats: An Isobologram Analysis, Neurobiology of Learning and Memory (2017)
22. Critical Role of Ca1 Muscarinic Receptors on Memory Acquisition Deficit Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
23. Recovery From Ketamine-Induced Amnesia by Blockade of Gaba-A Receptor in the Medial Prefrontal Cortex of Mice, Neuroscience (2017)
24. The Role of Ca3 Gabaa Receptors on Anxiolytic-Like Behaviors and Avoidance Memory Deficit Induced by Nmda Receptor Antagonists, Journal of Psychopharmacology (2016)
25. Role of Ca1 Gabaa and Gabab Receptors on Learning Deficit Induced by D-Ap5 in Passive Avoidance Step-Through Task, Brain Research (2018)
26. 5-Ht1a Receptor Blockade Targeting the Basolateral Amygdala Improved Stress-Induced Impairment of Memory Consolidation and Retrieval in Rats, Neuroscience (2015)
27. Pre-Mating Administration of Theophylline Could Prevent the Transgenerational Effects of Maternal Morphine Dependence on Offspring Anxiety Behavior: The Role of Dopamine Receptors, Pharmacology Biochemistry and Behavior (2023)
28. Serotonin-1A Receptor Activation in the Median Raphe Nucleus Improves Response Learning-Based Strategy in 192Igg Saporin-Induced Cognitive Impairments, European Journal of Pharmacology (2022)
29. Additive Effect of Bla Gabaa Receptor Mechanism and (+)-Mk-801 on Memory Retention Deficit, an Isobologram Analysis, Pharmacology Biochemistry and Behavior (2016)
30. Interaction Between Dorsal Hippocampal Nmda Receptors and Lithium on Spatial Learning Consolidation in Rats, Brain Research Bulletin (2016)
31. Synergistic Effect Between Prelimbic 5-Ht3 and Cb1 Receptors on Memory Consolidation Deficit in Adult Male Sprague-Dawley Rats: An Isobologram Analysis, Neuroscience (2016)
32. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway, Dementia and Geriatric Cognitive Disorders Extra (2022)
33. The Modulatory Effect of Nitric Oxide in Pro- and Anti-Convulsive Effects of Vasopressin in Ptz-Induced Seizures Threshold in Mice, Epilepsy Research (2016)
34. Hippocampal Dhcr24 Down Regulation in a Rat Model of Streptozotocin-Induced Cognitive Decline, Neuroscience Letters (2015)
35. Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Nanoformulation Against the Ischemic Neural Injuries, Life Sciences (2018)
36. Application of Nanostructured Lipid Carriers: The Prolonged Protective Effects for Sesamol in in Vitro and in Vivo Models of Ischemic Stroke Via Activation of Pi3k Signalling Pathway, DARU# Journal of Pharmaceutical Sciences (2017)
37. Pre- and Post-Treatment of Α-Tocopherol on Cognitive, Synaptic Plasticity, and Mitochondrial Disorders of the Hippocampus in Icv-Streptozotocin-Induced Sporadic Alzheimer’S-Like Disease in Male Wistar Rat, Frontiers in Neuroscience (2023)
38. Transgenerational Influence of Parental Morphine Exposure on Pain Perception, Anxiety-Like Behavior and Passive Avoidance Memory Among Male and Female Offspring of Wistar Rats, EXCLI Journal (2019)
39. Arbutin Intervention Ameliorates Memory Impairment in a Rat Model of Lysolecethin Induced Demyelination: Neuroprotective and Anti-Inflammatory Effects, Behavioural Brain Research (2024)
40. Cholestasis and Behavioral Disorders, Gastroenterology and Hepatology from Bed to Bench (2021)
41. The Influence of Dopaminergic System in Medial Prefrontal Cortex on Ketamine-Induced Amnesia in Passive Avoidance Task in Mice, European Journal of Pharmacology (2016)