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Activation of Trpv1 Receptors Affects Memory Function and Hippocampal Trpv1 and Creb Mrna Expression in a Rat Model of Biliary Cirrhosis Publisher Pubmed



Bashiri H1 ; Hosseinichegeni H2 ; Alsadat Sharifi K3 ; Sahebgharani M4 ; Salari AA5, 6
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Center, Institute of Neuropharmacology, Department of Physiology and Pharmacology, Afzalipour School of Medical, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Iran

Source: Neurological Research Published:2018


Abstract

Objective: Memory impairment induced by biliary cirrhosis is associated with abnormalities in the function of different neurotransmitter systems. However, the exact molecular mechanisms involved in the learning and memory dysfunctions following biliary cirrhosis is largely unknown. This study set out to determine whether activation of transient receptor potential vanilloid type 1 (TRPV1) in the CA1 area of the hippocampus in rats improve memory impairment induced by biliary cirrhosis.Methods: To assess learning and memory, passive avoidance task was carried out using a shuttle box. The mRNA expression of TRPV1 and cAMP response element binding (CREB) protein in the hippocampus were also evaluated by qT-PCR.Results: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis. Our findings also demonstrated that a positive correlation existed between mRNA expression of TRPV1 and CREB, and between memory function and TRPV1 expression.Discussion: Taken together, the results of this study support the view that TRPV1 receptor may play an important role in the regulation of learning and memory functions, and suggest that activation of TRPV1 channels seems to be a promising therapeutic target for learning and memory impairments following biliary cirrhosis. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
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