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Synergistic Effect Between Prelimbic 5-Ht3 and Cb1 Receptors on Memory Consolidation Deficit in Adult Male Sprague-Dawley Rats: An Isobologram Analysis Publisher Pubmed



Ahmadimahmoodabadi N1 ; Nasehi M1, 2 ; Emam Ghoreishi M3, 4 ; Zarrindast MR1, 5, 6, 7
Authors
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Authors Affiliations
  1. 1. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  2. 2. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  7. 7. Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Source: Neuroscience Published:2016


Abstract

The serotonergic system has often been defined as a neuromodulator system, and is specifically involved in learning and memory via its various receptors. Serotonin is involved in many of the same processes affected by cannabinoids. The present study investigated the influence of bilateral post-training intra-prelimbic (PL) administrations of serotonergic 5-hydroxytryptamine type-3 (5-HT3) receptor agents on arachidonylcyclopropylamide (ACPA) (cannabinoid CB1 receptor agonist)-induced amnesia, using the step-through inhibitory avoidance (IA) task to assess memory in adult male Sprague-Dawley rats. The results indicated that sole intra-PL microinjection of ACPA (0.1 and 0.5 μg/rat) and 5-HT3 serotonin receptor agonist (m-Chlorophenylbiguanide hydrochloride, m-CPBG; 0.001, 0.01 and 0.1 μg/rat) impaired, whereas Y-25130 (a selective 5-HT3 serotonin receptor antagonist; 0.001 and 0.01 and 0.1 μg/rat) did not alter IA memory consolidation, by itself. Moreover, intra-PL administration of subthreshold dose of m-CPBG (0.0005. μg/rat) potentiated, while Y-25130 (0.1 μg/rat) restored ACPA-induced memory consolidation deficit. The isobologram analysis showed that there is a synergistic effect between ACPA and m-CPBG on memory consolidation deficit. These findings suggest that 5-HT3 receptor mechanism(s), at least partly, play(s) a role in modulating the effect of ACPA on memory consolidation in the PL area. © 2015 IBRO.
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