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The Promising Role of Non-Coding Rnas As Biomarkers and Therapeutic Targets for Leukemia Publisher Pubmed



Ghazimoradi MH1 ; Karimpourfard N2 ; Babashah S1
Authors
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Authors Affiliations
  1. 1. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 1411713116, Iran
  2. 2. Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Genes Published:2023


Abstract

Early-stage leukemia identification is crucial for effective disease management and leads to an improvement in the survival of leukemia patients. Approaches based on cutting-edge biomarkers with excellent accuracy in body liquids provide patients with the possibility of early diagnosis with high sensitivity and specificity. Non-coding RNAs have recently received a great deal of interest as possible biomarkers in leukemia due to their participation in crucial oncogenic processes such as proliferation, differentiation, invasion, apoptosis, and their availability in body fluids. Recent studies have revealed a strong correlation between leukemia and the deregulated non-coding RNAs. On this basis, these RNAs are also great therapeutic targets. Based on these advantages, we tried to review the role of non-coding RNAs in leukemia. Here, the significance of several non-coding RNA types in leukemia is highlighted, and their potential roles as diagnostic, prognostic, and therapeutic targets are covered. © 2023 by the authors.
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