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A Systematic Review of Long Non-Coding Rnas With a Potential Role in Breast Cancer Publisher Pubmed



Heidari R1, 2 ; Akbariqomi M2 ; Asgari Y1 ; Ebrahimi D3 ; Alinejadrokny H4, 5, 6
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Biomedical Informatics Lab, Texas Biomedical Research Institute, San Antonio, 78227, TX, United States
  4. 4. BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, 2052, NSW, Australia
  5. 5. Core Member of UNSW Data Science Hub, The University of New South Wales (UNSW Sydney), Sydney, 2052, NSW, Australia
  6. 6. Health Data Analytics Program Leader, AI-enabled Processes (AIP) Research Centre, Macquarie University, Sydney, 2109, Australia

Source: Mutation Research - Reviews in Mutation Research Published:2021


Abstract

The human transcriptome contains many non-coding RNAs (ncRNAs), which play important roles in gene regulation. Long noncoding RNAs (lncRNAs) are an important class of ncRNAs with lengths between 200 and 200,000 bases. Unlike mRNA, lncRNA lacks protein-coding features, specifically, open-reading frames, and start and stop codons. LncRNAs have been reported to play a role in the pathogenesis and progression of many cancers, including breast cancer (BC), acting as tumor suppressors or oncogenes. In this review, we systematically mined the literature to identify 65 BC-related lncRNAs. We then perform an integrative bioinformatics analysis to identify 14 lncRNAs with a potential regulatory role in BC. The biological function of these 14 lncRNAs, their regulatory mechanisms, and roles in the initiation and progression of BC are discussed in this review. Additionally, we elaborate on the current and future applications of lncRNAs as diagnostic and/or therapeutic biomarkers in BC. © 2021 Elsevier B.V.
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