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Signaling Pathways Governing the Behaviors of Leukemia Stem Cells Publisher



Azizidoost S1 ; Nasrolahi A2 ; Sheykhisabzehpoush M3 ; Anbiyaiee A4 ; Khoshnam SE5 ; Farzaneh M6 ; Uddin S7
Authors
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Authors Affiliations
  1. 1. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6193673111, Iran
  2. 2. Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6193673111, Iran
  3. 3. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, 2193672411, Iran
  4. 4. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6193673111, Iran
  5. 5. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6193673111, Iran
  6. 6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6193673111, Iran
  7. 7. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, 3050, Qatar

Source: Genes and Diseases Published:2024


Abstract

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis. © 2023 Chongqing Medical University
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